Fig. 11
From: Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice
Pathway analysis (a), as well as genomic locations (b) and gene expression (c) of lncRNA-PCG pairs that were differentially regulated by lack of gut microbiota in BAT of CV and GF mice. (a) The PCGs paired with lncRNAs between CV and GF mice in BAT were subjected to STRING analysis using the default settings. The connected nodes are shown. (b) and (c) The circadian rhythm gene nocturnin (Noct/Ccrn4l) and the glutamine and sodium ion cotransporter Slc38a3 are shown. Expression of lncRNAs and paired PCGs were plotted using mean FPKM ± S.E., and asterisks (*) indicate statistically significant differences between enterotypes of mice (FDR-BH < 0.05)