Fig. 13

Pathway analysis (a), as well as genomic locations (b) and gene expression (c) of lncRNA-PCG pairs that were differentially regulated by lack of gut microbiota in skeletal muscle of CV and GF mice. (a) The PCGs paired with lncRNAs between CV and GF mice in skeletal muscle were subjected to STRING analysis using the default settings. The connected nodes are shown. (b) and (c) The muscle stretch response gene ankyrin repeat domain 2 (Ankrd2) and the voltage-gated potassium channel protein potassium voltage-gated channel, subfamily G, member 4 (Kcng4) are shown. Expression of lncRNAs and paired PCGs were plotted using mean FPKM ± S.E., and asterisks (*) indicate statistically significant differences between enterotypes of mice (FDR-BH < 0.05)