Fig. 6

Pathway analysis (a), as well as genomic locations (b) and gene expression (c) of examples of lncRNA-PCG pairs that were differentially regulated by lack of gut microbiota in duodenum of CV and GF mice. (a) PCGs paired with lncRNAs in duodenum between CV and GF mice were subjected to STRING analysis using the default settings. The connected nodes are shown. (b) and (c) The sodium bicarbonate transporter solute carrier (Slc) 4a7, the phase-I oxidation enzyme Cyp3a25, and the sodium-dependent purine transporter Slc28a2 are shown. Expression of lncRNAs and paired PCGs were plotted using mean FPKM ± S.E., and asterisks (*) indicate statistically significant differences between enterotypes of mice (FDR-BH < 0.05)