From: Genomic identification and functional analysis of essential genes in Caenorhabditis elegans
let-name | Essential gene | Alleles | Allele mutation (nucleic acid) | Allele mutation (Protein) | Pfam | KOG | Evolutionary conservatior |
---|---|---|---|---|---|---|---|
let-609 | let-363 | h191 | C- > T | R- > X | Phosphatidylinositol 3- and 4-kinase | Replication, recombination and repair | I,F,M,N |
let-643 | nath-10 | h500 | G- > A | R- > K | GNAT acetyltransferase 2 | General function prediction only | I,F,M,N |
let-624/ let-644/ let-622 | npp-6 | h449,h839,h222 | C- > T | Q- > X | Nucleoporin Nup120/160 | Unkown | I,F,M,N |
let-610 | asd-2 | h695 | C- > T | P- > S | Homodimerisation region of STAR domain protein | RNA processing and modification | I,F,M,N |
let-639/ let-371 | hcp-6 | h779,h123 | G- > A | W- > X | non-SMC mitotic condensation complex subunit 1 | Function unknown | I,F,M,N |
let-138/ let-150/ let-357 | spg-7 | h744,h282,h89 | G- > A | W- > X | Peptidase family M41 | Posttranslational modification, protein turnover, chaperones | I,F,M,N |
let-163 | sep-1 | h483 | C- > T | Q- > X | Peptidase family C50 | Cell cycle control, cell division. Chromosome partitioning | F,M,N |
let-133 | Y71G12B.8 | h440 | T- > A | Y- > X | DEAD/DEAH box helicase | RNA processing and modification | I,F,M,N |
let-593 | inx-13 | h212 | C- > T | Q- > X | Innexin | Unkown | I,F,N |
let-625 | rpl-4 | h506 | G- > A | D- > N | Ribosomal protein L4/L1 family | RNA processing and modification | I,F,M,N |
let-633/ let-638 | B0261.1 | h696,h778 | C- > T | R- > X | Myb DNA-binding like | Transcription | I,F,M,N |
let-648 | vha-16 | h781 | G- > A | D- > N | Unkown | Unkown | I,N,M,F |
let-615 | rpl-13 | h529 | C- > T | Q- > X | Ribosomal protein L13e | Translation, ribosomal structure and biogenesis | I,F,M,N |
let-356 | cdc-6 | h501 | G- > A | G- > R | ATPase family associated with various cellular activities (AAA) | Cell cycle control, cell division. Chromosome partitioning;Replication, recombination and repair | I,F,M,N |
let-505 | tufm-2 | h426 | C- > T | R- > X | Elongation factor Tu GTP binding domain | Translation, ribosomal structure and biogenesis | I,F,M,N |
let-128 | C53H9.2 | h253 | 465 + 1G > A | None | 50S ribosome-binding GTPase | General function prediction only | I,F,M,N |
let-398 | gpc-2 | h257 | C- > T | Q- > X | GGL domain | Signal transduction mechanisms | I,F,M,N |
let-619/ let-105 | dip-2 | h348,h681 | C- > T | H- > Y | AMP-binding enzyme | General function prediction only | I,F,M,N |
let-649/ let-109 | him-1 | h491,h811 | G- > A | G- > R | RecF/RecN/SMC N terminal domain | Cell cycle control, cell division. Chromosome partitioning | I,N,M,F |
let-578 | npp-11 | h512 | G- > A | W- > X | Nucleoporin FG repeat region | Intracellular trafficking, secretion, and vesicular transport;Nuclear structure | I,F,M,N |
let-543/ let-544 | sacy-1 | h792,h692 | G- > A | G- > R | DEAD/DEAH box helicase | RNA processing and modification | I,F,M,N |
let-614 | rmh-1 | h147 | C- > T | S- > L | RecQ mediated genome instability protein | Function unknown | F,N |
let-582 | egg-4 | h726 | G- > A | A- > T | Protein-tyrosine phosphatase | Signal transduction mechanisms | I,F,M,N |
let-528 | cytb-5.2 | h1012 | G- > A | W- > X | Cytochrome b5-like Heme/Steroid binding domain | Energy production and conversion | I,F,M,N |
let-511 | W09C3.4 | h755 | 262-1G > A | None | RNA polymerase Rpc34 subunit | Transcription | I,F,M,N |
let-135 | pop-1 | h268 | G- > A | A- > T | HMG (high mobility group) box | Transcription | I,F,M,N |
let-502 | spe-5 | h767 | C- > T | S- > F | ATP synthase alpha/beta family, nucleotide-binding domain | Energy production and conversion | I,F,M,N |
let-143 | npp-13 | h513 | G- > A | G- > E | Nup93/Nic96 | Cell cycle control, cell division. Chromosome partitioning | I,F,M,N |
let-571 | eif-2gamma | h347 | G- > A | G- > R | Initiation factor eIF2 gamma, C terminal | Translation, ribosomal structure and biogenesis | I,F,M,N |
let-155 | inx-21 | h461 | C- > T | R- > X | Innexin | Unkown | I,F,N |
let-162 | Y47G6A.18 | h460 | G- > A | G- > E | Golgi phosphoprotein 3 (GPP34) | Intracellular trafficking, secretion, and vesicular transport | I,F,M,N |
let-510 | Y47G6A.19 | h740 | 1355-1G > A | None | Zinc carboxypeptidase | Function unknown | I,F,M,N |
let-357 | lpd-3 | h132 | 1539 + 1G > A | None | Fragile site-associated protein C-terminus | Unkown | I,F,M,N |
let-546 | xpo-2 | h227 | G- > A | W- > X | Cse1 | Intracellular trafficking, secretion, and vesicular transport;Nuclear structure | I,F,M,N |
let-121/ let-146 | cdt-1 | h810,h197 | C- > T | Q- > X | DNA replication factor CDT1 like | Unkown | I,F,M,N |
let-130 | lpr-1 | h773 | G- > A | R- > Q | Unkown | Unkown | F,N |
let-573 | rpl-1 | h247 | C- > T | T- > I | Ribosomal protein L1p/L10e family | Translation, ribosomal structure and biogenesis | I,F,M,N |
let-145 | arx-1 | h182 | C- > T | Q- > X | Actin | Cytoskeleton | I,F,M,N |
let-123/ let-142/ let-583 | cogc-3 | h413,h518,h738 | G- > A | G- > R | Sec34-like family | Intracellular trafficking, secretion, and vesicular transport | I,F,M,N |
let-577 | sop-3 | h503 | G- > A | E- > K | Unkown | Unkown | F,M,N |
let-548/ let-144 | tln-1 | h356,h393 | C- > T | Q- > X | Talin, middle domain | Cytoskeleton | I,F,M,N |
let-131 | Y71G12B.6 | h817 | C- > T | Q- > X | GDP-mannose 4,6 dehydratase | Unkown | F,N |
let-392 | nekl-2 | h120,h122 | G- > A | G- > E | Protein kinase domain | General function prediction only | F,M,N |
let-374 | lpd-5 | h251 | G- > A | W- > X | Unkown | Unkown | I,F,M,N |