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Table 1 Biological functions of the identified 44 essential genes

From: Genomic identification and functional analysis of essential genes in Caenorhabditis elegans

let-name Essential gene Alleles Allele mutation (nucleic acid) Allele mutation (Protein) Pfam KOG Evolutionary conservatior
let-609 let-363 h191 C- > T R- > X Phosphatidylinositol 3- and 4-kinase Replication, recombination and repair I,F,M,N
let-643 nath-10 h500 G- > A R- > K GNAT acetyltransferase 2 General function prediction only I,F,M,N
let-624/ let-644/ let-622 npp-6 h449,h839,h222 C- > T Q- > X Nucleoporin Nup120/160 Unkown I,F,M,N
let-610 asd-2 h695 C- > T P- > S Homodimerisation region of STAR domain protein RNA processing and modification I,F,M,N
let-639/ let-371 hcp-6 h779,h123 G- > A W- > X non-SMC mitotic condensation complex subunit 1 Function unknown I,F,M,N
let-138/ let-150/ let-357 spg-7 h744,h282,h89 G- > A W- > X Peptidase family M41 Posttranslational modification, protein turnover, chaperones I,F,M,N
let-163 sep-1 h483 C- > T Q- > X Peptidase family C50 Cell cycle control, cell division. Chromosome partitioning F,M,N
let-133 Y71G12B.8 h440 T- > A Y- > X DEAD/DEAH box helicase RNA processing and modification I,F,M,N
let-593 inx-13 h212 C- > T Q- > X Innexin Unkown I,F,N
let-625 rpl-4 h506 G- > A D- > N Ribosomal protein L4/L1 family RNA processing and modification I,F,M,N
let-633/ let-638 B0261.1 h696,h778 C- > T R- > X Myb DNA-binding like Transcription I,F,M,N
let-648 vha-16 h781 G- > A D- > N Unkown Unkown I,N,M,F
let-615 rpl-13 h529 C- > T Q- > X Ribosomal protein L13e Translation, ribosomal structure and biogenesis I,F,M,N
let-356 cdc-6 h501 G- > A G- > R ATPase family associated with various cellular activities (AAA) Cell cycle control, cell division. Chromosome partitioning;Replication, recombination and repair I,F,M,N
let-505 tufm-2 h426 C- > T R- > X Elongation factor Tu GTP binding domain Translation, ribosomal structure and biogenesis I,F,M,N
let-128 C53H9.2 h253 465 + 1G > A None 50S ribosome-binding GTPase General function prediction only I,F,M,N
let-398 gpc-2 h257 C- > T Q- > X GGL domain Signal transduction mechanisms I,F,M,N
let-619/ let-105 dip-2 h348,h681 C- > T H- > Y AMP-binding enzyme General function prediction only I,F,M,N
let-649/ let-109 him-1 h491,h811 G- > A G- > R RecF/RecN/SMC N terminal domain Cell cycle control, cell division. Chromosome partitioning I,N,M,F
let-578 npp-11 h512 G- > A W- > X Nucleoporin FG repeat region Intracellular trafficking, secretion, and vesicular transport;Nuclear structure I,F,M,N
let-543/ let-544 sacy-1 h792,h692 G- > A G- > R DEAD/DEAH box helicase RNA processing and modification I,F,M,N
let-614 rmh-1 h147 C- > T S- > L RecQ mediated genome instability protein Function unknown F,N
let-582 egg-4 h726 G- > A A- > T Protein-tyrosine phosphatase Signal transduction mechanisms I,F,M,N
let-528 cytb-5.2 h1012 G- > A W- > X Cytochrome b5-like Heme/Steroid binding domain Energy production and conversion I,F,M,N
let-511 W09C3.4 h755 262-1G > A None RNA polymerase Rpc34 subunit Transcription I,F,M,N
let-135 pop-1 h268 G- > A A- > T HMG (high mobility group) box Transcription I,F,M,N
let-502 spe-5 h767 C- > T S- > F ATP synthase alpha/beta family, nucleotide-binding domain Energy production and conversion I,F,M,N
let-143 npp-13 h513 G- > A G- > E Nup93/Nic96 Cell cycle control, cell division. Chromosome partitioning I,F,M,N
let-571 eif-2gamma h347 G- > A G- > R Initiation factor eIF2 gamma, C terminal Translation, ribosomal structure and biogenesis I,F,M,N
let-155 inx-21 h461 C- > T R- > X Innexin Unkown I,F,N
let-162 Y47G6A.18 h460 G- > A G- > E Golgi phosphoprotein 3 (GPP34) Intracellular trafficking, secretion, and vesicular transport I,F,M,N
let-510 Y47G6A.19 h740 1355-1G > A None Zinc carboxypeptidase Function unknown I,F,M,N
let-357 lpd-3 h132 1539 + 1G > A None Fragile site-associated protein C-terminus Unkown I,F,M,N
let-546 xpo-2 h227 G- > A W- > X Cse1 Intracellular trafficking, secretion, and vesicular transport;Nuclear structure I,F,M,N
let-121/ let-146 cdt-1 h810,h197 C- > T Q- > X DNA replication factor CDT1 like Unkown I,F,M,N
let-130 lpr-1 h773 G- > A R- > Q Unkown Unkown F,N
let-573 rpl-1 h247 C- > T T- > I Ribosomal protein L1p/L10e family Translation, ribosomal structure and biogenesis I,F,M,N
let-145 arx-1 h182 C- > T Q- > X Actin Cytoskeleton I,F,M,N
let-123/ let-142/ let-583 cogc-3 h413,h518,h738 G- > A G- > R Sec34-like family Intracellular trafficking, secretion, and vesicular transport I,F,M,N
let-577 sop-3 h503 G- > A E- > K Unkown Unkown F,M,N
let-548/ let-144 tln-1 h356,h393 C- > T Q- > X Talin, middle domain Cytoskeleton I,F,M,N
let-131 Y71G12B.6 h817 C- > T Q- > X GDP-mannose 4,6 dehydratase Unkown F,N
let-392 nekl-2 h120,h122 G- > A G- > E Protein kinase domain General function prediction only F,M,N
let-374 lpd-5 h251 G- > A W- > X Unkown Unkown I,F,M,N
  1. Table includes 44 identified essential genes in this study with the information of let-x name, Alleles, Allele mutation, biological functions, and evolutionary conservation. N-Nematodes, I-Invertebrates (Drosophila), M-Mammals (mouse, human), F-Fungi (Saccharomycetaceae)