Fig. 5

a, Hierarchical clustering of F. prausnitzii strains and type strains of other species of the family Ruminococcaceae based on the gene orthologues content. Orthologous protein products were grouped using OrthoMCL. Clustering performed with Euclidean distances using Ward.D2 algorithm. F. prausnitzii clade highlighted in red. Clustering identified 245 non-paralogous single copy genes constituting the core genome of the family. b, Maximum-likelihood phylogenetic tree of the family Ruminococcaceae based on concatenated alignments of 245 highly conserved proteins. Phylogeny inference done with PROTGAMMABLOSUM62 model, 100 bootstrap replicates. Phylogroups I, IIa, and IIb highlighted in red, purple and light blue respectively