Fig. 6

Impact of dsCBP on gene expression. (a) Heatmap illustrating the TMM normalized expression values of 456 down-regulated genes (p < 0.01, ≤ 2-fold ↓) after dsCBP treatment in TcA cells. (b) Venn diagram representing the genes that were commonly affected by dsCBP treatment in vitro, in vivo (data not shown), and induced after TSA treatment. Twenty-two genes (X) were common in between all the comparisons (MD vs. CD, MD vs. MT, dsCBP in vivo) whereas thirteen genes (Y) were common in between comparisons such as MD vs. CD and MD vs. MT. (c) Heatmap showing the expression of selected genes that were represented as ‘X’ and ‘Y’ in section (b) after treatments of interest. [MD: dsmalE treated cells exposed to DMSO; CD: dsCBP treated cells exposed to DMSO; MT: dsmalE treated cells exposed to TSA]