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Table 3 Selection of differentially expressed genes in P. aeruginosa in co-culture versus mono-culture

From: Transcriptional profiling of Pseudomonas aeruginosa and Staphylococcus aureus during in vitro co-culture

gene FC a annotation functional category
Up-regulated genes
lldA 14.13 L-lactate dehydrogenase metabolism
 PA14_19690 7.77 CidB, LrgB anti-holin protein cell envelope
 PA14_19680 6.51 CidA, LrgA holin like protein cell envelope
fdnH 5.55 nitrate inducible formate DH accessory protein metabolism
 PA14_64270 5.08 Leu/Ile/Val-binding protein family signature transport
 PA14_55631 5.05 23S ribosomal RNA RNA synthesis/modif.
 PA14_62060 5.05 23S ribosomal RNA RNA synthesis/modif.
 PA14_61830 4.88 tRNA-Met RNA synthesis/modif.
 PA14_63100 4.38 cytochrome type D-lactate DH (4Fe-4S) metabolism
narK1 3.95 nitrite extrusion protein I transport
 PA14_24780 3.87 Amoonium transporter transport
lldD 3.64 L-lactate dehydrogenase metabolism
 PA14_60150 3.26 tRNA-Lys RNA synthesis/modif.
popN 3.13 type III secretion system virulence
 PA14_08670 3.01 tRNA-Thr RNA synthesis/modif.
 PA14_08660 2.96 tRNA-Gly RNA synthesis/modif.
lldP 2.94 L-lactate permease transport
ureE 2.93 urease accessory protein UreE metabolism
glnA 2.93 glutamine synthetase N-metabolism
mtr 2.74 Tryptophan permease transport
 PA14_36220 2.61 Amino acid permease transport
exsB 2.56 TTSS regulator virulence
 PA14_08210 2.52 F-pyocin Phage/pyocin
gdhA 2.49 glutamate dehydrogenase N-metabolism
 PA14_06890 2.36 pyruvate kinase pyridoxal phosphate metabolism
 PA14_06930 2.32 glutamine amidotransferase metabolism
 PA14_08070 2.30 R-pyocin, phage tail protein Phage/pyocin
 PA14_06920 2.04 class III pyridoxal phosphate aminotransferase metabolism
Down-regulated genes
 PA14_37310 −20.35 allophanate hydrolase subunit II putative metabolism
 PA14_37290 −18.80 allophanate hydrolase subunit I putative metabolism
 PA14_37270 −18.65 LamB/YcsF, carbohydrate/lactam utilization metabolism
mmsB −16.48 3-hydroxyisobutyrate dehydrogenase aa metabolism
mmsA −15.68 methylmalonate-semialdehyde dehydrogenase aa metabolism
 PA14_37260 −15.13 OpdO, lactam/pyroglutamate uptake transport
pchB −14.79 pyochelin synthesis virulence
 PA14_37250 −12.58 MFS transporter transport
bkdA1 −11.87 2-oxoisovalerate dehydrogenase subunit alpha aa metabolism
gnuT −11.53 gluconate permease transport
pchC −11.32 pyochelin synthesis virulence
pchG −10.48 pyochelin synthesis virulence
pchA −9.97 pyochelin synthesis virulence
pchF −9.56 pyochelin synthesis virulence
 PA14_23010 −9.47 GltK, ATP-binding component of ABC transporter transport
 PA14_23000 −9.37 permease of ABC sugar transporter transport
 PA14_22990 −9.19 permease of ABC sugar transporter transport
 PA14_23030 −8.63 OprB, Glucose/carbohydrate porin transport
bkdA2 −8.05 2-oxoisovalerate dehydrogenase subunit beta aa metabolism
bdhA −5.81 3-hydroxybutyrate dehydrogenase metabolism
bkdB −4.93 branched-chain alpha-keto acid dehydrogenase metabolism
lpdV −3.58 dihydrolipoamide dehydrogenase metabolism
fptA −4.85 pyochelin receptor virulence
mexG −4.32 RND efflux pump transport
mexH −4.12 RND efflux pump transport
opmD −3.49 RND efflux pump transport
mexI −3.43 RND efflux pump transport
coxA −3.90 Cytochrome c oxidase subunit I energy metabolism
coxB −2.98 Cytochrome c oxidase subunit II energy metabolism
PA14_01310 −2.64 Cytochrome c oxidase assembly protein energy metabolism
coIII −2.15 Cytochrome c oxidase subunit III energy metabolism
napF −2.97 periplasmic nitrate reducatse N-metabolism
napE −2.45 periplasmic nitrate reducatse N-metabolism
  1. aFC fold change; values are the average of three replicates after normalization