Fig. 8

CCM-induced gene expression changes mirror those that occur during aging. (a-c) Scatterplots with week 3 CCM-induced log2FC graphed on the x-axis and week 2 CCM-induced log2FC graphed on the y-axis for all genes (a), week 3 downregulated genes (b) and week 3 upregulated genes (c). Each dot represented an individual gene. For all genes (a) n = 14,062; Spearman rho = 0.237 (95% confidence interval: 0.221 to 0.252); p < 1.0E-15. For week 3 downregulated genes (b) n = 245; Spearman rho = 0.043 (95% confidence interval: − 0.082 to 0.168); p = 0.499. For week 3 upregulated genes (c) n = 104; Spearman rho = 0.297 (95% confidence interval: 0.111 to 0.463); p = 2.20E-3. (d-f) Scatterplots with week 2 or 3 CCM-induced log2FC graphed on the x-axis and aging-induced log2FC graphed on the y-axis for all week 2 differentially expressed genes (d), week 3 downregulated genes (e), and week 3 upregulated genes (f). Each dot represents an individual gene. Red dots indicate genes that are oppositely regulated by CCM and aging. See Table 5 for a list of these oppositely regulated genes