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Table 3 Overrepresented GO Terms Associated with Week 3 Differentially Expressed Genes

From: Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

GO ID GO Term Adjusted p-Value Number of Genes Fold Enrichment
--Terms Associated with Downregulated Genes--
 GO:0048869 cellular developmental process 5.90E-34 109 3.6
 GO:0048468 cell development 1.02E-32 97 4.0
 GO:0030154 cell differentiation 1.13E-32 106 3.6
 GO:0007275 multicellular organism development 1.02E-31 123 3.0
 GO:0048731 system development 7.36E-29 102 3.4
 GO:0048513 animal organ development 1.39E-21 76 3.7
 GO:0007399 nervous system development 2.15E-21 72 3.9
 GO:0010468 regulation of gene expression 7.02E-21 84 3.3
 GO:0009888 tissue development 4.72E-20 69 3.8
 GO:0032989 cellular component morphogenesis 1.11E-19 55 4.8
 GO:0022008 neurogenesis 1.51E-19 62 4.2
 GO:0009790 embryo development 7.70E-19 49 5.2
 GO:0009889 regulation of biosynthetic process 7.12E-18 74 3.3
 GO:0007389 pattern specification process 7.83E-18 46 5.3
 GO:0051128 regulation of cellular component organization 2.56E-17 56 4.2
--Terms Associated with Upregulated Genes--
 GO:0009636 response to toxic substance 5.59E-05 10 9.0
 GO:0051186 cofactor metabolic process 1.13E-04 12 6.5
 GO:0006790 sulfur compound metabolic process 1.06E-03 9 7.6
 GO:0061077 chaperone-mediated protein folding 6.69E-03 5 15.2
 GO:0008340 determination of adult lifespan 9.98E-03 8 6.6
 GO:0051085 chaperone cofactor-dependent protein refolding 1.02E-02 4 22.3
 GO:0046680 response to DDT 1.21E-02 3 44.6
 GO:0007568 aging 1.41E-02 8 6.3
 GO:0009408 response to heat 1.83E-02 6 9.1
 GO:0006979 response to oxidative stress 2.14E-02 7 7.1
 GO:0055114 oxidation-reduction process 3.19E-02 14 3.3
 GO:0009266 response to temperature stimulus 3.71E-02 7 6.5
 GO:0034620 cellular response to unfolded protein 4.73E-02 4 15.3
  1. Adjusted p-value is based on Bonferroni correction. Number of genes refers to genes annotated with that term out of the 245 week 3 downregulated genes or 104 week 3 upregulated genes. Fold enrichment is compared to the relative prevalence of genes annotated with the term in the full set of Drosophila coding genes.