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Table 3 Overrepresented GO Terms Associated with Week 3 Differentially Expressed Genes

From: Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

GO ID

GO Term

Adjusted p-Value

Number of Genes

Fold Enrichment

--Terms Associated with Downregulated Genes--

 GO:0048869

cellular developmental process

5.90E-34

109

3.6

 GO:0048468

cell development

1.02E-32

97

4.0

 GO:0030154

cell differentiation

1.13E-32

106

3.6

 GO:0007275

multicellular organism development

1.02E-31

123

3.0

 GO:0048731

system development

7.36E-29

102

3.4

 GO:0048513

animal organ development

1.39E-21

76

3.7

 GO:0007399

nervous system development

2.15E-21

72

3.9

 GO:0010468

regulation of gene expression

7.02E-21

84

3.3

 GO:0009888

tissue development

4.72E-20

69

3.8

 GO:0032989

cellular component morphogenesis

1.11E-19

55

4.8

 GO:0022008

neurogenesis

1.51E-19

62

4.2

 GO:0009790

embryo development

7.70E-19

49

5.2

 GO:0009889

regulation of biosynthetic process

7.12E-18

74

3.3

 GO:0007389

pattern specification process

7.83E-18

46

5.3

 GO:0051128

regulation of cellular component organization

2.56E-17

56

4.2

--Terms Associated with Upregulated Genes--

 GO:0009636

response to toxic substance

5.59E-05

10

9.0

 GO:0051186

cofactor metabolic process

1.13E-04

12

6.5

 GO:0006790

sulfur compound metabolic process

1.06E-03

9

7.6

 GO:0061077

chaperone-mediated protein folding

6.69E-03

5

15.2

 GO:0008340

determination of adult lifespan

9.98E-03

8

6.6

 GO:0051085

chaperone cofactor-dependent protein refolding

1.02E-02

4

22.3

 GO:0046680

response to DDT

1.21E-02

3

44.6

 GO:0007568

aging

1.41E-02

8

6.3

 GO:0009408

response to heat

1.83E-02

6

9.1

 GO:0006979

response to oxidative stress

2.14E-02

7

7.1

 GO:0055114

oxidation-reduction process

3.19E-02

14

3.3

 GO:0009266

response to temperature stimulus

3.71E-02

7

6.5

 GO:0034620

cellular response to unfolded protein

4.73E-02

4

15.3

  1. Adjusted p-value is based on Bonferroni correction. Number of genes refers to genes annotated with that term out of the 245 week 3 downregulated genes or 104 week 3 upregulated genes. Fold enrichment is compared to the relative prevalence of genes annotated with the term in the full set of Drosophila coding genes.