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Table 5 Genes Oppositely Regulated by Circadian Misalignment and Aging

From: Chronic circadian misalignment results in reduced longevity and large-scale changes in gene expression in Drosophila

gene name week 3 log2FC week 3 p-adj aging log2FC aging p-adj function
--Downregulated with CCM; Upregulated with Aging--
CG3739 −0.90 3.70E-13 0.20 2.38E-01 dipeptidyl-peptidase activity; serine-type peptidase activity
CG18609 −0.80 7.72E-13 0.56 4.94E-04 fatty acid elongase activity
 CG34180 −0.75 1.46E-03 0.50 1.04E-01 unknown
 CG10960 −0.67 1.49E-06 0.51 4.81E-03 carbohydrate:proton symporter activity; glucose transmembrane transporter activity
 CG11741 −0.56 4.57E-02 0.67 3.26E-02 unknown
b6 −0.55 4.23E-02 0.38 1.79E-01 unknown
 Uro −0.54 2.75E-02 0.57 3.79E-02 urate oxidase activity
 rost −0.51 2.96E-02 0.35 1.14E-01 unknown
 CG4607 −0.48 7.35E-03 0.58 1.96E-04 carbohydrate:proton symporter activity; glucose transmembrane transporter activity
 CG15096 −0.46 9.90E-02 0.48 4.42E-02 transmembrane transporter activity
 CG9459 −0.35 8.04E-02 0.71 1.34E-03 fatty acid elongase activity
 CG14464 −0.33 9.77E-02 0.46 1.09E-02 unknown
--Upregulated with CCM; Downregulated with Aging--
 CG5804 0.51 7.70E-03 −0.36 1.68E-01 fatty-acyl-CoA binding
 CG5767 0.45 4.87E-02 −0.65 6.97E-03 unknown
 CG34330 0.41 3.14E-02 −0.22 2.57E-01 unknown
 AsnS 0.37 7.58E-02 −0.36 8.08E-02 asparagine synthase (glutamine-hydrolyzing) activity; protein homodimerization activity
  1. log2FC determined by DEseq2 using shrinkage estimation. p-adj is the False Discovery Rate (FDR) as determined by Benjamini-Hochberg correction. Italicized genes were also significantly downregulated following 2 weeks of CCM exposure.