Fig. 6

Occurrence of putative miRNA target sites in circRNA exons. a Putative target sites normalized by exon length in differentially conserved sets. “All targets” represents no conservation at all. Apis represents conservation only in closely related species. Eusocial insects are sufficiently distant to consider conservation relevant. The number of miRNA binding sites conserved in this set is significantly higher (p<0.001, Students t-test) than in the control. The absolute number of potential binding sites in the respective sets is given in parentheses below. b Illustration of miRNAs with potential target sites in circRNAs conserved even in eusocial insects. Only miRNAs with at least ten target sites and an at least five-fold enrichment over control are shown. Error bars indicate standard deviation in fold enrichment between different controls (N=42)