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Fig. 2 | BMC Genomics

Fig. 2

From: RNA sequencing identifies common pathways between cigarette smoke exposure and replicative senescence in human airway epithelia

Fig. 2

Significant overlap between replicative senescence- and CSE-induced gene expression changes. a Overlap in genes differentially regulated versus control in CSE-treated and senescent pPHBECs. b Number of genes significantly up- or downregulated at FDR < 0.05 in CSE or senescence conditions. c Genes upregulated in both CSE and senescence conditions. Bars show normalized and log-scaled mean expression scores (FPKM+ 1) ± SEM. d Genes downregulated in both CSE and senescence conditions. e Immunoblot analysis for HMOX1 and S100A9 in control, CSE-exposed (both P1: passage 1) or senescent (Sen) pHBECs isolated from two donors

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BMC Genomics

ISSN: 1471-2164

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