Table 3 KEGG pathways of differentially expressed miRNAs
From: MicroRNA expression profile of HCT-8 cells in the early phase of Cryptosporidium parvum infection
Hsa-miRNA | Pathway | Gene | P value |
|---|---|---|---|
miR-34b-5p | Ubiquitin mediated proteolysis | CBLB, CBL, NHLRC1, BTRC, NEDD4, PIAS1 | 0.0073 |
AMPK signaling pathway | ELAVL1, RAB10, RAB14, CREB1, HNF4, APRKA2 | 0.04 | |
Notch signaling pathway | APH1A, DLL1, JAG1, NOTCH1, NOTCH2 | 0.017 | |
Hippo signaling pathway | MOB1B, WNT2B, BTRC, BMPR2, DLG1, GSK3B | 0.013 | |
miR-942-5p | Ras signaling pathway | RAF1, TEK, CHUK, FGF9MAPK10, MRAS… | 0.006 |
ErbB signaling pathway | RAF1, CDKN1B, MAPK10, NRAS, PAK2, PIK3CD | 0.0082 | |
MAPK signaling pathway | RAF1, TAOK1, TAB2, CACNA1E, CHUK,… | 0.014 | |
Wnt signaling pathway | CREBBP, FBXW11, WNT9B, CCND1… | 0.022 | |
p53 signaling pathway | CHEK1, CCND1, RFWD2, SERPINE1, ZMAT3 | 0.046 | |
PI3K-Akt signaling pathway | MCL1, RAF1, TEK, COL4A5, CHUK, CCND1… | 0.047 | |
miR-3591-3 | Ubiquitin mediated proteolysis | CBLHERC3, CDC27, CUL5, MAP3K1, RFWD2... | 0.0049 |
ErbB signaling pathway | SOS2, CAMK2A, MAP2K4, NRG3, STAT5B | 0.016 | |
MAPK signaling pathway | ELK4, SOS2, TAB2, DAXX, FGF14, MAP2K3… | 0.017 | |
miR-6721-5p | Cell adhesion molecules (CAMs) | CD22, CD276, CD40LG, CD8A, CADM3, CLDN19. | 0.0018 |
ErbB signaling pathway | CDKN1A, AKT2, ELK1, SRC, CAMK2A… | 0.0037 | |
Ras signaling pathway | ABL1, AKT2, BCL2L1, ELK1, GNB2, RASA4B… | 0.0087 | |
cGMP-PKG signaling pathway | AKT2, ATP1A2, ATP2B2, GNA11, GNAI2… | 0.018 | |
Let-7b-3p | Chemokine signaling pathway | AKT2, CX3CR1, CRKL, CRK, GNAI3, GNB4… | 0.044 |
actin cytoskeleton | CDC42RKL, GNA13, ROCK1, ROCK2, SOS2… | 0.0086 | |
MAPK signaling pathway | CDC42, AKT2, CRKL, CRK, MECOM, RAP1B… | 0.00085 | |
AMPK signaling pathway | HMGCR, PFKFB3, AKT2, ELAVL1, RAB10… | 0.018 | |
Notch signaling pathway | DLL1, DLL4, HES1, JAG1, JAG2, MAML2, RBPJ… | 0.031 | |
Wnt signaling pathway | LRP6, ROCK2, WNT5B, CTNNB1, CUL1… | 0.0085 | |
TGF-beta signaling pathway | ROCK1, SP1, ACVR1, ACVR2B, BMPR2, CUL1... | 0.0085 | |
cGMP-PKG signaling pathway | AKT2, ATP2B1, GNA13, GNAI3, ROCK1… | 0.0036 | |
miR-454-5p | Central carbon metabolism | AKT3, MAPK1, PDGFRA | 0.012 |
Rap1 signaling pathway | AKT3, MAPK1, PDGFRA, TLN2 | 0.016 | |
miR-1287-3p | Ras signaling pathway | ABL2, BCL2L1, RAB5A, EFNA3, FGF12 | 0.021 |
miR-3121-5p | Cell adhesion molecules | CLDN2, HLA-C, NRXN1, PTPRF, SELE, SDC1 | 0.017 |
Cytokine receptor interaction | CXCL14, KIT, RELT, TNFRSF21, ACVR1… | 0.034 | |
miR-1256 | ErbB signaling pathway | KRAS, EGF, PIK3CG, TGFA | 0.014 |
Ras signaling pathway | KRAS, RAP1B, EGF, PIK3, CGRAC1, STK4 | 0.0093 | |
MAPK signaling pathwa | KRAS, MKNK2, RAP1B, TAB2, STK4… | 8.50E-5 | |
Rap1 signaling pathway | KRAS, RAP1B, RAPGEF2, EGF, PIK3CG, RAC1 | 0.0068 | |
miR-4685-3p | Inflammatory mediator regulation of TRP channels | ASIC1, ADCY3, ITPR2, MAP2K6 | 0.017 |
miR-5580-3p | ECM-receptor interaction | COL5A2, COL11A1, ITGA2, ITGA4, ITGA9 | 0.049 |