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Table 3 Ranking of the top 10 upregulated and downregulated differentially expressed genes in the poly(I:C) dataset. Ranking based on fold change

From: Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line

Gene ID Name Fold change p value FDR
A
TNFSF10 507,215 tumor necrosis factor superfamily member 10, transcript variant X1 3838.1 1.5 × 10−17 4.1 × 10− 15
IFIT2 527,528 interferon induced protein with tetratricopeptide repeats 2 2354.2 7.8 × 10− 16 1.5 × 10− 13
RSAD2 506,415 radical S-adenosyl methionine domain containing 2 2258.9 1.9 × 10−28 5.2 × 10− 25
IFI44L 508,347 interferon induced protein 44 like 2010.7 2.8 × 10−15 4.8 × 10− 13
OAS1a 347,699 2′,5′-oligoadenylate synthetase 1, 40/46 kDa 1591.7 9.7 × 10− 23 5.3 × 10− 20
IFI44 508,348 interferon induced protein 44, transcript variant X1 1254.3 1.8 × 10− 13 2.6 × 10− 11
ISG15 281,871 ISG15 ubiquitin-like modifier 1033.6 4.9 × 10−30 1.6 × 10−26
MX1 280,872 MX dynamin-like GTPase 1, transcript variant X2 967.8 1.8 × 10−27 3.6 × 10− 24
MX2 280,873 MX dynamin-like GTPase 2, transcript variant X1 895.4 4.0 × 10− 20 1.4 × 10−17
OAS2 529,660 2′-5′-oligoadenylate synthetase 2 807.5 8.7 × 10− 12 9.9 × 10− 10
B
CYP1A1 282,870 cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1, transcript variant X2 −3.8 8.1 × 10− 12 9.3 × 10− 10
EXOC3L2 539,328 exocyst complex component 3-like 2 − 3.7 1.2 × 10− 4 3.3 × 10− 3
USH1G 531,104 Usher syndrome 1G (autosomal recessive) − 3.3 1.3 × 10− 3 2.1 × 10− 2
CYP26B1 540,868 cytochrome P450, family 26, subfamily B, polypeptide 1 − 3.1 1.9 × 10− 3 2.8 × 10− 2
SMIM17 100,849,034 small integral membrane protein 17, transcript variant X4 − 2.9 1.5 × 10− 3 2.3 × 10− 2
DAAM2 783,665 dishevelled associated activator of morphogenesis 2, transcript variant X1 − 2.8 1.1 × 10− 3 1.9 × 10− 2
TMEM52 617,403 transmembrane protein 52 − 2.7 3.5 × 10− 3 4.4 × 10− 2
CYP1B1 511,470 cytochrome P450, family 1, subfamily B, polypeptide 1 − 2.6 6.8 × 10− 11 6.9 × 10− 9
WASF3 540,674 WAS protein family member 3, transcript variant X4 −2.3 2.7 × 10− 3 3.1 × 10− 2
ATOH8 616,225 atonal bHLH transcription factor 8, transcript variant X1 − 2.2 9.5 × 10− 10 8.2 × 10− 8
  1. (A) upregulated, (B) downregulated. Data were analyzed in IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis