Table 5 Top 5 Canonical pathways generated by Ingenuity Pathway Analysis (IPA) of differentially expressed genes in Bomac cells stimulated with PAMPs (A) CpG DNA vs control, (B) poly(I:C) vs control. https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis
| Â | Canonical Pathway | p-Value | Ratio | Molecules |
|---|---|---|---|---|
A | Sperm Motility | 3.6 × 10−4 | 4.8 × 10−2 | CNGA, GUY1B3, MST1R, PDE4B, PLA2G12B, PRKCB |
Nur77 Signaling in T Lymphocytes | 9.9 × 10−4 | 6.8 × 10−2 | CD3G, HDACG, HLA-DMB, NR4A1 | |
Xenobiotic Metabolism Signaling | 1.5 × 10−3 | 2.8 × 10−2 | CYP1A1, CYP1B1, FTL, HMOXX1, HS3ST2, MAP3K13, MAP3K14 | |
Calcium-induced T Lymphocyte Apoptosis | 1.5 × 10−3 | 6.1 × 10−2 | CD3G, HLA-DMB, NRA41, PRKCB, | |
Coagulation System | 2.3 × 10−3 | 8.6 × 10−2 | BDKRB1, PLAU, PLAUR, | |
B | Interferon Signaling | 2.1 × 10−17 | 4.17 × 10–1 | SOCS1, IFIT3, OAS1, MX1, IRF9, IFI35, PSMB8, TAP1, IRF1, ISG15, IFIT1, STAT2, IFI6, STAT1, IFITM1 |
Activation of IRF by Cytosolic Pattern Recognition Receptors | 2.3 × 10− 13 | 2.42 × 10− 1 | DHX58, NFKBIE, ZBP1, IRF9, IRF3, ADAR, ISG15, IFIH1, IRF7, NFKBIA, CD40, DDX58, STAT2, IFIT2, STAT1 | |
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 4.6 × 10− 10 | 1.24 × 10− 1 | CXCL8, OAS1, C3, OAS2, CCL5, IRF3, RNASEL, TLR2, IFIH1, IRF7, DDX58, TGFB3, PRKCH, IRS2, EIF2AK2, RIPK2, C3AR1 | |
Death Receptor Signaling | 1.1 × 10−9 | 1.52 × 10−1 | GAS2, DAXX, NFKBIA, PARP10, NFKBIE, ZC3HAV1, TNFSF10, PARP12, PARP3, CASP8, BIRC3, PARP9, CASP7, PARP14 | |
Antigen Presentation Pathway | 1.9 × 10−8 | 2.37 × 10−1 | B2M, PSMB9, NLRC5, HLA-B, HLA-DMB, CIITA, PSMB8, TAP1, TAP2 |