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Table 5 Top 5 Canonical pathways generated by Ingenuity Pathway Analysis (IPA) of differentially expressed genes in Bomac cells stimulated with PAMPs (A) CpG DNA vs control, (B) poly(I:C) vs control. https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis

From: Bacterial and viral pathogen-associated molecular patterns induce divergent early transcriptomic landscapes in a bovine macrophage cell line

  Canonical Pathway p-Value Ratio Molecules
A Sperm Motility 3.6 × 10−4 4.8 × 10−2 CNGA, GUY1B3, MST1R, PDE4B, PLA2G12B, PRKCB
Nur77 Signaling in T Lymphocytes 9.9 × 10−4 6.8 × 10−2 CD3G, HDACG, HLA-DMB, NR4A1
Xenobiotic Metabolism Signaling 1.5 × 10−3 2.8 × 10−2 CYP1A1, CYP1B1, FTL, HMOXX1, HS3ST2, MAP3K13, MAP3K14
Calcium-induced T Lymphocyte Apoptosis 1.5 × 10−3 6.1 × 10−2 CD3G, HLA-DMB, NRA41, PRKCB,
Coagulation System 2.3 × 10−3 8.6 × 10−2 BDKRB1, PLAU, PLAUR,
B Interferon Signaling 2.1 × 10−17 4.17 × 10–1 SOCS1, IFIT3, OAS1, MX1, IRF9, IFI35, PSMB8, TAP1, IRF1, ISG15, IFIT1, STAT2, IFI6, STAT1, IFITM1
Activation of IRF by Cytosolic Pattern Recognition Receptors 2.3 × 10− 13 2.42 × 10− 1 DHX58, NFKBIE, ZBP1, IRF9, IRF3, ADAR, ISG15, IFIH1, IRF7, NFKBIA, CD40, DDX58, STAT2, IFIT2, STAT1
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 4.6 × 10− 10 1.24 × 10− 1 CXCL8, OAS1, C3, OAS2, CCL5, IRF3, RNASEL, TLR2, IFIH1, IRF7, DDX58, TGFB3, PRKCH, IRS2, EIF2AK2, RIPK2, C3AR1
Death Receptor Signaling 1.1 × 10−9 1.52 × 10−1 GAS2, DAXX, NFKBIA, PARP10, NFKBIE, ZC3HAV1, TNFSF10, PARP12, PARP3, CASP8, BIRC3, PARP9, CASP7, PARP14
Antigen Presentation Pathway 1.9 × 10−8 2.37 × 10−1 B2M, PSMB9, NLRC5, HLA-B, HLA-DMB, CIITA, PSMB8, TAP1, TAP2