The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms

Table 3 Analysis of the highly differentially expressed genes following 3MCA injection

	Immune	ECM	Hypoxia	Cell cycle	Citrate cycle	Degenerative diseases	# of genes
HDEG^a	125	269	164	239	74	159	888
DE^b	43	57	88	84	9	21	220
TSU^c S > M^d	13	14	8	6	1	5	39
TSU M > S^d	4	4	3	5	–	5	21
TPD^e S < M^f	4	7	14	9	–	4	36
TPD M < S^f	4	9	6	6	–	5	27

^aHDEG highly differentially expressed genes |log2f| ≥2
^bDE Differentially Expressed—the number of HDEG refers to when the difference in the change between the species following the 3-MCA injection is |log2f| ≥1
^cTSU Tumor Suppressors Up-regulated
^dS > M, M > S: higher elevation in the Spalax compared to the mice, or the mice compared to the Spalax, respectively
^eTPD Tumor Promoters Down-regulated
^fS < M, M < S: stronger down-regulation in the Spalax compared to the mice, or the mice compared to Spalax, respectively

ISSN: 1471-2164