Fig. 8

Proposed models of A. oryzae 112822 in response to nicotine exposure. The models were based on the results in the present study and in the existing literature (see Discussion for details). The proteins in red represent the induced enzymes. The dashed arrows represent the speculated information. CS, citrate synthase; AH, aconitate hydratase; IDH, isocitrate dehydrogenase; α-KGDC, α-ketoglutarate dehydrogenase complex; SCS, succinyl-CoA synthetase; SDH, succinate dehydrogenase; FH, fumarate hydratase; MDH, malate dehydrogenase; KOT, kynurenine 2-oxoglutarate transaminase; OPLAH, 5-oxoprolinase (ATP-hydrolysing); gshB, GSH synthase; GSTs, glutathione S-transferases; ABC, ATP-Binding Cassette; MFS, major facilitator superfamily; CYP, cytochrome P450 monooxygenase; Hsp, heat shock protein; SOD, superoxide dismutase; CAT, catalase; Prx, peroxiredoxin; Ku70, ATP-dependent DNA helicase 2 subunit 1; RAD50, DNA repair protein RAD50; Pol4, DNA polymerase IV; Dnl4, DNA ligase 4; ER, endoplasmic reticulum