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Table 2 TF-mediated regulation of genes via induced enhancers

From: Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection

TF Motifs # overlapping enhancers # target DEGs
AP-1 (FOSL1::JUNB, FOSL2::JUNB, JUNB, FOSL2, FOSL1) 128 (49.8%) 180 (68.4%)
NF-kB (REL, RELA, NFKB2) 117 (45.5%) 157 (59.7%)
RBPJ 117 (45.5%) 160 (60.8%)
IRF1 88 (34.2%) 126 (47.9%)
Nfe2l2 54 (21%) 86 (32.7%)
JDP2 53 (20.6%) 92 (35%)
Total (12 motifs) 229 (89.1%) 250 (95.1%)
  1. Columns show individual TF motifs or their groups, number and percentage of overlapping enhancers among the induced enhancers, number and percentage of DEGs targeted by these enhancers among the 263 DEGs up-regulated at 4 h and associated with the induced enhancers