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Table 3 Top 50 down-regulated DEGs at 15 h relative to 5 h time-point

From: RNA-sequencing analysis of shell gland shows differences in gene expression profile at two time-points of eggshell formation in laying chickens

Gene symbol

Gene name

Fold change

FDR

SLC13A5

Solute carrier family 13 member 5

−6.516

1.99E-07

KLB

Klotho beta

−5.998

0.00079

XAF1

XIAP associated factor 1

−5.316

9.26E-05

FIBIN

Fin bud initiation factor homolog (zebrafish)

−4.894

1.40E-07

POMGNT1

Protein O-linked mannose N-acetylglucosaminyltransferase 1 (Beta 1,2-)

−4.828

0.00026

MMP13

Matrix metallopeptidase 13

−4.673

0.00089

CTNNA3

Catenin alpha 3

−4.625

0.00239

GJA8

Gap junction protein alpha 8

−4.522

0.00089

CA9

Carbonic anhydrase 9

−4.519

0.00042

HABP2

Hyaluronan binding protein 2

−4.464

0.00119

ARHGAP25

Rho GTPase-activating protein 25

−4.284

1.18E-06

SEMA3G

Semaphorin 3G

−4.254

3.39E-06

fibrinogen

Fibrinogen beta chain

−4.199

0.00057

CYP7A1

Cytochrome P450 family 7 subfamily A member 1

−4.170

0.00081

ADPRHL1

ADP-ribosylhydrolase like 1

− 4.103

0.00035

GHRHR

Growth hormone releasing hormone receptor

−4.075

0.0037

TCERG1L

Transcription elongation regulator 1 like

−3.925

4.38E-05

FREM2

FRAS1 related extracellular matrix protein 2

− 3.835

0.00608

NR1D1

Nuclear receptor subfamily 1, group D, member 1

−3.785

0.00235

EVPL

Envoplakin

−3.749

1.20E-05

ODZ1

Teneurin transmembrane protein 1

−3.732

0.00339

TDT

DNA nucleotidylexotransferase

3.714

0.00241

SAMD7

Sterile alpha motif domain containing 7

−3.620

0.00405

HAS2

Hyaluronan synthase 2

−3.564

0.00034

PCBP2

Poly (RC) binding protein 2

−3.548

0.00125

SLC25A15

Solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

−3.545

4.48E-05

ADRA2A

Adrenoceptor alpha 2A

−3.512

0.00042

CBX2

Chromobox 2

−3.484

0.00497

TNFSF10

Tumor necrosis factor superfamily member 10

−3.475

5.95E-05

SLC26A4

Solute carrier family 26 member 4

−3.467

0.03297

NTN1

Netrin 1

−3.449

0.01807

VWD

Von Willebrand Factor

−3.448

0.00591

PLA2G4E

Cytosolic phospholipase A2 epsilon-like

−3.409

0.03367

DAB1

DAB1, reelin adaptor protein

−3.383

0.00025

FAM159A

Family with sequence similarity 159 member A

−3.347

0.00295

AMER2

APC membrane recruitment protein 2

− 3.299

0.00011

GRXCR1

Glutaredoxin and cysteine rich domain containing 1

−3.205

0.05005

BCAS1

Breast carcinoma amplified sequence 1

− 3.197

0.0048

SLC13A2

Solute carrier family 13 member 2

−3.162

2.00E-05

NF2L

Neurofibromin 2 (merlin)-like

−3.111

0.00156

CGA

Glycoprotein hormones, alpha polypeptide

−3.078

0.01157

C8B

Complement C8 beta chain

−3.063

0.01559

SYT15

Synaptotagmin 15

−3.055

0.00329

RASD1

Ras related dexamethasone induced 1

−3.047

5.25E-06

KCNA1

Potassium voltage-gated channel subfamily A member 1

−3.045

0.01937

GATA3

GATA-binding factor 3

−3.036

1.18E-06

PLA2G4F

Phospholipase A2 group IVF

−3.029

0.03613

SRL

Sarcalumenin

−2.959

0.00252

DSC1

Desmocollin 2

−2.954

0.00012

ANO3

Anoctamin-3 isoform 1

− 2.933

0.00307

  1. Fold change (FC) was calculated in log2 value. Minus (−) sign shows down-regulation of the genes at the 15 h relative to the 5 h time-point