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Table 5 Top 10 shared genetic pathways shared between RA and butyric acid

From: Data-driven multiple-level analysis of gut-microbiome-immune-joint interactions in rheumatoid arthritis

Pathway

Enrichment Fold (RA)

Enrichment fold (butyric acid)

Combined

IL27-mediated signaling events

10.31

6.48

7.96

IL-10 Anti-inflammatory Signaling Pathway

9.47

6.60

7.78

Th1/Th2 Differentiation

16.94

4.73

7.39

Cytokines and Inflammatory Response

9.25

5.03

6.52

NO2-dependent IL 12 Pathway in NK cells

9.47

4.62

6.21

Erythrocyte Differentiation Pathway

7.15

5.24

6.05

IL 2 signaling pathway

7.31

5.10

6.01

Cytokine Network

7.31

5.10

6.01

IL22 Soluble Receptor Signaling Pathway

6.70

4.91

5.67

Regulation of hematopoiesis by cytokines

10.73

3.74

5.55