Table 8 Comparative analyses of sex-related genes from Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Crassostrea hongkongensis and Incilaria fruhstorferi

Sox (E group)

Sry-related HMG-box

yes (Sox8, Sox9, Sox10)

yes (sox100B)

yes (Sox8)

Sox (B1 group)

yes (Sox3)

yes (Sox3)

yes (Sox2)

Sox (A group)

Sex-determining region Y

yes (Sry)

yes (Sry)

GATA

GATA-binding protein

yes (GATA4)

yes (GATA4)

yes (GATA14, GATA1, GATA10)

MAP 3 K

Mitogen-associated protein3 kinase

yes (MAP 3 K1, MAP 3 K4)

yes (MAP 3 K1, MAP 3 K4)

ATRX

ATP-dependent helicase

yes

yes (dATRX)

yes (xnp-1)

yes

yes

Hhat

Hedgehog acyltransferase

yes

yes

yes

yes

yes

Wnt4

wingless-type family member 4

yes

yes

yes

β-catenin

beta-catenin

yes

armadillo

yes

yes

CYP11B

Cytochrome P450 family 11 subfamily B

yes

CYP19A1

Cytochrome P450 family 19 subfamily A1

yes

fgf9

fibroblast growth factor 9

yes

GADD45

Growth arrest and DNA-damage inducible protein 45

yes

yes

yes (GADD45 gamma, GADD45 beta)

RSPO1

RSpondin1

yes

yes

Fem1/3

Sex-determining protein fem

yes

yes

yes

yes

LHX9

LIM homeobox gene 9

yes

yes

WT1

Wilms tumor protein 1

yes

yes

Sf1

Steroidogenic factor 1

yes

CBX-2

Chromobox-homolog 2

yes

yes

EMX-2

Empty Spiracles homeobox 2

yes

AMH and AMHR

Anti-Mullerian hormone and AMH Receptor

yes

DMRT

Doublesex and mab-3 related transcription factor

yes

dsx

MAB-3

DHH

Desert Hedgehog

yes

yes

Kdm3a

Histone demethylase

yes

yes

Dax1

Dosage-sensitive Sex Reversal Adrenal Hypoplasia critical region on X-chromosome

yes

yes

Six

sineoculis homeobox

yes

yes

yes

yes

GSDF

Gonadal soma derived growth factor

yes

PDGF

Platelet-derived growth factor

yes (PDRFα, PDRFβ)

AR

Androgen Receptor

yes

FOXL2

Forkhead box protein L2

yes

yes

FST

follistatin

yes

yes

Era

Estrogen receptor

yes

yes

Sdc

Sex-determination and dosage compensation

yes

yes

yes

Tra

Transformer

yes

yes

yes

yes

yes

Fru

fruitless

yes