Fig. 10

CREB3L3 deficiency during ketogenic diet leads to upregulation of the cell cycle. a Top 20 upregulated genesets in liver of CREB3L3−/− mice compared with wild-type mice, determined by geneset enrichment analysis and ranked according to normalized enrichment score (NES) (blue). The NES of the same genesets for the comparison between wild-type and PPARα−/− (red) or combined PPARα/CREB3L3−/− (purple) mice is shown as well. b Comparative gene expression analysis in liver of wild-type, PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice after a 4-day ketogenic diet. The genes shown are the 20 most highly enriched genes in CREB3L3−/− mice vs. wild-type mice that are part of the geneset CELL.CYCLE.MITOTIC. c Comparative gene expression analysis in liver of wild-type, PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice after a 4-day ketogenic diet, showing the top 40 most highly upregulated genes in CREB3L3−/− mice. d Comparative gene expression analysis in liver of wild-type mice, wild-type mice treated with Wy-14,643 for 5 days, PPARα−/− mice, and PPARα−/− treated with Wy-14,643 for 5 days (left panel), and wild-type, PPARα−/−, CREB3L3−/−, and combined PPARα/CREB3L3−/− mice after a 4-day ketogenic diet (right panel). The genes shown are the 20 most highly enriched genes upon Wy-14.643 treatment that are part of the geneset MITOTIC.M.M.G1 PHASE. Red indicates upregulated, blue indicates downregulated