Prioritizing candidate genes for fertility in dairy cows using gene-based analysis, functional annotation and differential gene expression

Table 1 Lead SNPs from genome-wide associated regions for female fertility in Nordic Holstein cattle

BTA	BP	effect	-log₁₀(P)	Interval	Gene (distance in bp)	Annotation
1	69,742,415	3.68	11.03	68,745,058~69,992,433	UMPS	intron
1^a	140,785,028	1.91	9.53	139,838,183~141,035,632	BRWD1	intron
6	95,867,927	2.15	11.80	95,377,650~96,118,034	GK2 (14,991)	intergenic
10	68,534,665	2.08	9.16	67,917,166~68,784,933	U7 snRNA (29,099)	intergenic
13	32,852,133	−3.09	16.48	31,866,274~33,102,422	SLC39A12 (100,247)	intergenic
17	71,393,345	1.83	8.54	70,501,607~71,656,270	LIF (20,510)	intergenic
24	29,556,826	2.32	10.18	28,794,256~29,807,379	ENSBTAG00000044212 (65,604)	intergenic

Base positions are given as positions in UMD 3.1.1 [49]. Lead SNPs identified in the second round are marked by^a. The method to define QTL intervals was described in Methods

ISSN: 1471-2164