Prioritizing candidate genes for fertility in dairy cows using gene-based analysis, functional annotation and differential gene expression

Table 3 Overlap gene between candidate genes and DEGs from previous study

Gene name	tissue	design	DE direction
FRAS1	uterine biopsies	pregnant vs non-pregnant animals [18]	Down
FRAS1	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
ITGB5	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Up
ITGB5	endometrium	pregnant vs non-pregnant subfertile animals [19]	Up
KLF6	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Up
MYLK	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
DIRC2	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Up
KALRN	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
ADCY5	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
ADCY5	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
SEMA5B	endometrium	pregnant vs non-pregnant subfertile animals [19]	Down
SEMA5B	endometrium	pregnant vs non-pregnant high-fertile animals [19]	Down
OTX2	conceptuses	subfertile vs high-fertile animals [19]	Up

Note, high-fertile (100% pregnancy rate) and subfertile (25 to 33% pregnancy rate) using serial transfer (n = 3 to 4 rounds) of a single in vitro-produced embryo on day 7 followed by pregnancy determination on day 28 [19]

ISSN: 1471-2164