Table 1 Enrichment of differentially expressed genes (DEGs) for known interactions (“interactome”) for each region and drug combination. The most enriched (up to 10) are shown for each brain region/drug combination
From: Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
Region | # interactions (p < 0.5) | Top interactions | p value |
|---|---|---|---|
ACB | 4 | YWHAZ interactions | 1.69E-06 |
IPPK interactions | 2.75E-06 | ||
MAP2K4 interactions | 4.12E-06 | ||
NANOG interactions | 4.31E-06 | ||
BLA | 23 | DLG4 interactions | 4.32E-23 |
DLGAP1 interactions | 2.05E-19 | ||
SYNGAP1 interactions | 5.91E-17 | ||
AGAP2 interactions | 4.43E-16 | ||
SHANK3 interactions | 1.87E-15 | ||
GRIN2B interactions | 2.49E-12 | ||
GRIN1 interactions | 9.86E-11 | ||
GRID2 interactions | 1.70E-09 | ||
DLG1 interactions | 2.44E-09 | ||
YWHAZ interactions | 5.69E-09 | ||
INS | 1 | NTRK1 interactions | 9.35E-07 |
PVT | 29 | DLGAP1 interactions | 2.26E-22 |
DLG4 interactions | 8.56E-22 | ||
AGAP2 interactions | 3.13E-20 | ||
SYNGAP1 interactions | 1.00E-19 | ||
SHANK3 interactions | 5.25E-19 | ||
GRIN2B interactions | 9.05E-15 | ||
GRIN1 interactions | 9.32E-14 | ||
GRIN2A interactions | 4.19E-13 | ||
YWHAZ interactions | 5.32E-10 | ||
KCNB1 interactions | 5.83E-10 |