Table 2 Known functions of candidate R5 target proteins (“common” list). Descriptions are from UniProt database (www.uniprot.org)

CACNA1A

Calcium Voltage-Gated Channel Subunit Alpha1 A

Voltage-sensitive calcium channel involved in neurotransmitter release

GRIP1

Glutamate Receptor Interacting Protein 1

Scaffold for multi-protein signalling complexes and mediator of trafficking of its binding partners, related to glutamate receptors.

DLG4

Discs Large MAGUK Scaffold Protein 4

Guanylate kinase (MAGUK) family member. Mediator of post-synaptic events; including plasticity via by interaction with cytoplasmic tail of NMDA receptor (NMDR), DLG2 and shaker type potassium channels following ligand binding.

GRIN1

Glutamate Ionotropic Receptor NMDA Type Subunit 1

NMDA receptor subunit associated with synaptic plasticity

GNAI1

Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-1

Signal transduction downstream of G-protein coupled receptor

DGUOK

Deoxyguanosine Kinase

Nucleoside kinase activity in mitochondria

KALRN

Kalirin RhoGEF Kinase

Signal transduction of pathways for neuronal shape, growth and plasticity mainly via effects on actin cytoskeleton

GRIN2A

Glutamate Ionotropic Receptor NMDA Type Subunit 2A

NMDA receptor subunit associated with long-term potentiation and efficiency of transmission

SHANK3

SH3 And Multiple Ankyrin Repeat Domains 3.

Scaffold protein between membrane proteins and cytoskeleton. Involved in signal transduction

YWHAZ

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta

Regulation of many signalling pathways via binding to phosphoserine containing proteins

CALM1

Calmodulin 1

Involved in control of function of many proteins and calcium-dependent inactivation of CACNA1C