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Table 2 Known functions of candidate R5 target proteins (“common” list). Descriptions are from UniProt database (www.uniprot.org)

From: Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

Common terms Description
CACNA1A
Calcium Voltage-Gated Channel Subunit Alpha1 A
Voltage-sensitive calcium channel involved in neurotransmitter release
GRIP1
Glutamate Receptor Interacting Protein 1
Scaffold for multi-protein signalling complexes and mediator of trafficking of its binding partners, related to glutamate receptors.
DLG4
Discs Large MAGUK Scaffold Protein 4
Guanylate kinase (MAGUK) family member. Mediator of post-synaptic events; including plasticity via by interaction with cytoplasmic tail of NMDA receptor (NMDR), DLG2 and shaker type potassium channels following ligand binding.
GRIN1
Glutamate Ionotropic Receptor NMDA Type Subunit 1
NMDA receptor subunit associated with synaptic plasticity
GNAI1
Guanine Nucleotide-Binding Protein G(I) Subunit Alpha-1
Signal transduction downstream of G-protein coupled receptor
DGUOK
Deoxyguanosine Kinase
Nucleoside kinase activity in mitochondria
KALRN
Kalirin RhoGEF Kinase
Signal transduction of pathways for neuronal shape, growth and plasticity mainly via effects on actin cytoskeleton
GRIN2A
Glutamate Ionotropic Receptor NMDA Type Subunit 2A
NMDA receptor subunit associated with long-term potentiation and efficiency of transmission
SHANK3
SH3 And Multiple Ankyrin Repeat Domains 3.
Scaffold protein between membrane proteins and cytoskeleton. Involved in signal transduction
YWHAZ
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta
Regulation of many signalling pathways via binding to phosphoserine containing proteins
CALM1
Calmodulin 1
Involved in control of function of many proteins and calcium-dependent inactivation of CACNA1C