Fig. 3
A potential senescence signature defined by altered gene expression after radiation and p21 overexpression. Venn Diagram analysis of the differentially expressed genes (DEGs) identified by microarray analysis of MCF7GFP-IBD cells, 5 days after 6 Gy irradiation, compared to MCF7p21 cells, 5 days after induction with doxycycline, determined by comparison to untreated controls. Shown are numbers of up- or down-regulated genes with fold change >1.5. Note high overlap between DEGs, with ~50% of all genes regulated by p21 also regulated by radiation, and very few displaying reciprocal expression.