Fig. 4
From: GAPPadder: a sensitive approach for closing gaps on draft genomes with short sequence reads
Pipeline of GAPPadder for closing gaps: a Align reads back to the draft genome and collect the first three types of relevant reads originated from the gaps. b Perform local assembly with the collected reads, and merge contigs overlapping with each other to generate more complete gap sequences. c Align the unmapped reads to the constructed contigs of each gap, and collect the aligned (also their mate) reads. d Merge the contigs to form more complete assembly. e Gap sequences are obtained by aligning the merged contigs to the flanking regions of the gaps