Expanding dynamics of the virulence-related gene variations in the toxigenic Vibrio cholerae serogroup O1

BMC Genomics

Table 1 The homologs of the virulence-related genes in V. cholerae with a coverage ratio for all the strains in the top 20%

Name	Total	Unique	Copy	Genotype	GeneNum/ Genotype	Core	Significance
Name	Total	Unique	Copy	Genotype	GeneNum/ Genotype	Core	①	②	③	④
ctxA	317	314	1	6	52.83	+				–
ctxB	320	314	1	10	32	+
flrA	919	314	1	10	91.9	+		+	+	+
fleR/flrC	1517	314	1	23	65.96	+
vasJ	314	314	0	6	52.33	+
mshJ	314	314	0	5	62.8	+				+
mshF	314	314	0	3	104.67	+
rtxB	3473	314	1	57	60.93	+
viuC	3984	314	1	41	97.17	+		+	+	+
tlh	314	314	0	3	104.67	+
epsM	314	314	0	2	157	+				+
epsG	314	314	0	1	314	+
viuD	922	314	1	8	115.25	+
vctD	314	314	0	3	104.67	+
flaA	1536	314	1	32	48	+		+	+
flgE	314	314	0	1	314	+
flgD	314	314	0	2	157	+
cheV	1246	314	1	15	83.07	+		+	+
fliQ	314	314	0	1	314	+
cheW	944	314	1	9	104.89	+				+
cheB	874	314	1	17	51.41	+		+	+	+
cheZ	314	314	0	2	157	+
cheY	1282	314	1	30	42.73	+		–	–	+
epsB	314	314	0	4	78.5	+				+
flgP	314	314	0	3	104.67	+				+
acfB	2059	313	1	32	64.34	–		+	+
ace	316	313	1	1	316	–				+
vasC	313	313	0	4	78.25	–				+
vasD	313	313	0	2	156.5	–				+
vasI	313	313	0	3	104.33	–				+
vipB/mglB	313	313	0	2	156.5	–				+
mshM	319	313	1	6	53.17	–				–
mshG	313	313	0	3	104.33	–
mshD	313	313	0	2	156.5	–
rtxB	1466	313	1	13	112.77	–		+	+

Note: Total: the number of genes in all strains; Unique: the number of strains having that gene; Copy: if the gene has duplicated genes in more than one strains, it tagged as 1, otherwise as 0. Genotype: the number of genotypes for the homolog. GeneNum/Genotype: the average number of genes of the homolog contributing to a genotype, i.e., the number of genes per genotype. Core: “+” indicates that it is a core virulence gene,“-” indicate it is not a core virulence gene. Significance: “+” indicates it is positive correlated with isolation years of strains, while “-” indicates it is negatively correlated with them; ① indicated the gain and loss of the gene;② indicated the number of genotypes of that homologous gene; ③ indicated the duplicated gene number in each strain; ④ indicated the gene variation

ISSN: 1471-2164