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Fig. 3 | BMC Genomics

Fig. 3

From: Histone H3 lysine 4 methyltransferase is required for facultative heterochromatin at specific loci

Fig. 3

Global profile of H3K9me3 and H3K4me3. (a) The heatmaps display H3K9me3 enrichment for a subset of genes in WT and kmt2/set-1. The blue arrow highlights genes enriched for H3K9me3 in the gene body in both WT and kmt2/set-1, while the blue arrow indicates transcripts that had elevated H3K9me3 in kmt2/set-1. (b) Similar to panel (a), except we examine H3K4me3 in WT and kmt1/dim-5. Three independent clusters show the spatial distribution of H3K4me3 for transcript identified in Fig. 1a and included 2 kb upstream of TSS and downstream of TES. Clusters not shown for H3K9me3 and H3K4me3 did not have a ChIP-seq peak associated with them. (c & d) The MAplots show quantitative difference in H3K9me3 peak densities between WT and kmt2/set-1 in (c) DD and (d) LP30. (e-f) Same as in (c) & (d) except differences in H3K4me3 peak densities were between WT and kmt1/dim-5. The red spots on the MA plots indicate a log fold change (p < 0.05)

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