Fig. 2

Differential expression of genes within enriched pathways during hibernation shared by all examined tissue. Mean (across biological replicates, ± 1 standard error) expression, measured in counts per million (CPM), of genes in brain (red), heart (green), and skeletal muscle (blue). Expression is shown for hibernators (triangles) and non-hibernators (circles). Panels a to d display genes related to gene expression regulatory mechanisms. Panels e to h display genes related to stress responses. The genes are from the following biological processes: a chromatin modification, b gene silencing by miRNA, c protein SUMOylation, d protein ubiquitination, e cell cycle arrest, f hypoxia response, g p38-MAPK signaling pathway, and h NF-κB signaling. All plotted on a log₁₀ scale