Fig. 1
From: Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Subsampling sites on the EPIC array to estimate a genome-wide significance threshold. Line graphs depicting the relationship between the number of EPIC array DNA methylation sites (x-axis) and a) the 5% family-wise error rate (FWER) (−log10(p-values); y-axis) and b) the mean effective number of tests (y-axis) estimated from 1000 simulated null association studies. Error bars present the 95% confidence intervals from 1000 simulations. The final point includes all DNA methylation sites on the EPIC array and therefore could not be resampled to generate a confidence interval