Table 2 Summary of statistical power to significantly detect differential methylation between cases and controls
From: Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Sample Size | Standard Deviation | |||||
|---|---|---|---|---|---|---|
0.01 | 0.03 | 0.05 | 0.07 | 0.09 | 0.15 | |
Mean Difference = 2% | ||||||
 100 | 100% | 1.26% | 0.03% | 0.00% | 0.00% | 0.00% |
 200 | 100% | 21.4% | 0.45% | 0.04% | 0.01% | 0.00% |
 500 | 100% | 97.8% | 17.6% | 1.43% | 0.19% | 0.01% |
 1000 | 100% | 100% | 82.7% | 19.7% | 3.22% | 0.06% |
Mean Difference = 5% | ||||||
 100 | 100% | 99.1% | 24.4% | 2.18% | 0.29% | 0.01% |
 200 | 100% | 100% | 93.0% | 32.0% | 6.07% | 0.11% |
 500 | 100% | 100% | 100% | 99.4% | 78.4% | 4.81% |
 1000 | 100% | 100% | 100% | 100% | 100% | 45.8% |