Fig. 3

Alignment of all nine condensation domains of the NRPS gene cluster. The alignment also includes the C8 condensation domain which was not predicted by antiSMASH. The conserved motif HHxxxDG is shown in red box. For C1, C7, C8 and C9 (the last condensation domain which acts as termination domain) the first H (His) is replaced by S (Ser) but the functionally important second H (His) residue of the motif is found conserved in all the condensation domain sequences