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Fig. 2 | BMC Genomics

Fig. 2

From: A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

Fig. 2

Developmental defects of Gam1-injected embryos. a Control (left) and Gam1-injected (right) late gastrula stage embryos showing delayed closure of the blastopore (arrow) in the latter. b Stage 35 (50 hpf) control embryo (left), Gam1 embryo with shortened A–P axis (center), Gam1 embryo with an open neural tube and edema around the heart (right). c An example of an eye defect (cyclopia). d Failure of the heart tube to initiate looping. (Left) A control embryo (96 hpf) in which the two atria (red) and ventricle (black) have fully developed compared to (right) a Gam1 embryo in which the heart tube has failed to undergo looping

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