Skip to main content

Advertisement

Table 1 Transcription Factor Network Buildinga

From: A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

Differential Gene Expression Constant Gene Expression
Early Gastrula (94) Late Gastrula (447) Early Neurula (742) Early Gastrula (11,702) Late Gastrula (11,322) Early Neurula (11,019)
SP1 15 HNF4α 104 SP1 119 HNF4α 1372 HNF4α 1335 HNF4α 1313
HNF4α 14 SP1 101 HNF4α 114 SP1 1082 SP1 1053 SP1 1028
c-Myc 13 c-Myc 92 c-Myc 106 c-Myc 1033 c-Myc 1002 c-Myc 987
p53 9 ESR1 75 p53 77 p53 486 p53 461 p53 460
Oct-3/4 7 p53 67 ESR1 69 ESR1 479 ESR1 463 ESR1 455
STAT3 6 E2F1 60 C/EBPβ 50 CREB1 467 CREB1 452 CREB1 451
CREB1 6 NF-Y 59 NF-kB 45 AP-1 378 AP-1 370 AP-1 365
YY1 5 AR 58 STAT1 38 NF-Y 310 E2F1 335 E2F1 332
HNF1α 4 EGR1 54 AR 37 E2F1 342 NF-Y 301 NF-Y 303
Sry 4 c-Jun 53 CREB1 37 NF-kB 314 NF-kB 302 NF-kB 298
FKHR 4 ETS1 53 HSF1 36 AP-2 306 AP-2 300 YY1 294
SRF 4 GCRα 53 MYOD 36 YY1 303 EGR1 293 AP-2 293
NANOG 4 YY1 52 SRF 36 EGR1 300 YY1 290 EGR1 289
E2F1 4 Oct-3/4 51 EGR1 36 GATA-1 283 GATA-1 276 GATA-1 266
ETS1 4 RelA 51 E2F1 36 Elk-1 214 Elk-1 211 Elk-1 206
EGR1 4 Oct-1 50 AP-1 35 ETS1 250 ETS1 248 ETS1 242
HIF1A 4 SRF 50 RelA 34 AR 258 AR 255 AR 249
AP-2 3 HIF1A 50 C/EBPα 32 HIF1A 236 HIF1A 233 Oct-3/4 232
ATF-6 α 3 MYOD 49 p21 32 C/EBPβ 235 C/EBPβ 230 c-Jun 224
RelA 3 C/EBPβ 49 ATF-2 31 Oct-3/4 236 E2F4 228 E2F4 223
C/EBPα 3 Bcl-6 48 YY1 29 c-Jun 233 Oct-3/4 227 HIF1A 222
ER81 3 TCF7L2 48 HIF1A 29 E2F4 229 c-Jun 222 C/EBPβ 217
HSF1 3 HSF1 48 p63 29 RelA 224 RelA 216 RelA 214
ESR1 3 HNF6 48 SP3 28 SP3 206 SP3 203 SP3 199
USF2 3 E2F4 47 NF-Y 28 GCRα 205 SRF 188 GCRα 198
AP-1 3 SMAD3 47 AP-4 28 HNF6 205 AP-2A 197 HNF6 198
AR 3 SOX4 47 c-Jun 27 Oct-1 202 HNF6 197 AP-2A 194
MYOD 3 STAT1 46 GATA-1 26 AP-2A 200 Oct-1 195 Oct-1 192
FOXO3A 3 c-Myb 46 STAT3 26 AHR 192 GCRα 195 HNF1α 187
AP-2A 3 SREBP1 46 Oct-3/4 24 HNF1α 192 AHR 189 SRF 185
  1. aTop 30 transcription factors associated the largest number of genes that are either differentially expressed or constant across developmental stages of Gam1 embryos built using the Transcription Factor Regulation algorithm in MetaCore. Numbers indicate the number of genes used for network building in each case