A deficiency in SUMOylation activity disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos

Table 1 Transcription Factor Network Building^a

Differential Gene Expression						Constant Gene Expression
Early Gastrula (94)		Late Gastrula (447)		Early Neurula (742)		Early Gastrula (11,702)		Late Gastrula (11,322)		Early Neurula (11,019)
SP1	15	HNF4α	104	SP1	119	HNF4α	1372	HNF4α	1335	HNF4α	1313
HNF4α	14	SP1	101	HNF4α	114	SP1	1082	SP1	1053	SP1	1028
c-Myc	13	c-Myc	92	c-Myc	106	c-Myc	1033	c-Myc	1002	c-Myc	987
p53	9	ESR1	75	p53	77	p53	486	p53	461	p53	460
Oct-3/4	7	p53	67	ESR1	69	ESR1	479	ESR1	463	ESR1	455
STAT3	6	E2F1	60	C/EBPβ	50	CREB1	467	CREB1	452	CREB1	451
CREB1	6	NF-Y	59	NF-kB	45	AP-1	378	AP-1	370	AP-1	365
YY1	5	AR	58	STAT1	38	NF-Y	310	E2F1	335	E2F1	332
HNF1α	4	EGR1	54	AR	37	E2F1	342	NF-Y	301	NF-Y	303
Sry	4	c-Jun	53	CREB1	37	NF-kB	314	NF-kB	302	NF-kB	298
FKHR	4	ETS1	53	HSF1	36	AP-2	306	AP-2	300	YY1	294
SRF	4	GCRα	53	MYOD	36	YY1	303	EGR1	293	AP-2	293
NANOG	4	YY1	52	SRF	36	EGR1	300	YY1	290	EGR1	289
E2F1	4	Oct-3/4	51	EGR1	36	GATA-1	283	GATA-1	276	GATA-1	266
ETS1	4	RelA	51	E2F1	36	Elk-1	214	Elk-1	211	Elk-1	206
EGR1	4	Oct-1	50	AP-1	35	ETS1	250	ETS1	248	ETS1	242
HIF1A	4	SRF	50	RelA	34	AR	258	AR	255	AR	249
AP-2	3	HIF1A	50	C/EBPα	32	HIF1A	236	HIF1A	233	Oct-3/4	232
ATF-6 α	3	MYOD	49	p21	32	C/EBPβ	235	C/EBPβ	230	c-Jun	224
RelA	3	C/EBPβ	49	ATF-2	31	Oct-3/4	236	E2F4	228	E2F4	223
C/EBPα	3	Bcl-6	48	YY1	29	c-Jun	233	Oct-3/4	227	HIF1A	222
ER81	3	TCF7L2	48	HIF1A	29	E2F4	229	c-Jun	222	C/EBPβ	217
HSF1	3	HSF1	48	p63	29	RelA	224	RelA	216	RelA	214
ESR1	3	HNF6	48	SP3	28	SP3	206	SP3	203	SP3	199
USF2	3	E2F4	47	NF-Y	28	GCRα	205	SRF	188	GCRα	198
AP-1	3	SMAD3	47	AP-4	28	HNF6	205	AP-2A	197	HNF6	198
AR	3	SOX4	47	c-Jun	27	Oct-1	202	HNF6	197	AP-2A	194
MYOD	3	STAT1	46	GATA-1	26	AP-2A	200	Oct-1	195	Oct-1	192
FOXO3A	3	c-Myb	46	STAT3	26	AHR	192	GCRα	195	HNF1α	187
AP-2A	3	SREBP1	46	Oct-3/4	24	HNF1α	192	AHR	189	SRF	185

^aTop 30 transcription factors associated the largest number of genes that are either differentially expressed or constant across developmental stages of Gam1 embryos built using the Transcription Factor Regulation algorithm in MetaCore. Numbers indicate the number of genes used for network building in each case

ISSN: 1471-2164