Table 4 Twenty orthologous genes with the highest dN/dS ratios between Cryptosporidium chipmunk genotype I and Cryptosporidium parvum

C_ch_8.3686

cgd2_90

1.25

YES

NO

YES

ABC transporter with 9 transmembrane domains and 2 AAA domains

C_ch_8.3664

cgd2_70

1.24

YES

NO

YES

ABC transporter, with 12 transmembrane domains and 2 AAA domains

C_ch_11.460

cgd3_60

1.15

NO

NO

YES

Putative hydrolase

C_ch_105.389

cgd5_4570

1.11

NO

NO

YES

Hypothetical protein with disordered regions

C_ch_10.167

cgd7_640

1.04

NO

NO

YES

Prp16p pre-mRNA splicing factor, HrpA family SFII helicase

C_ch_22.2069

cgd6_3780

1.04

YES

YES

NO

Hypothetical membrane protein with signal peptide and transmembrane domain

C_ch_10.307

cgd8_5370

0.99

YES

NO

YES

Conserved secreted protein

C_ch_37.2969

cgd7_5510

0.99

YES

NO

YES

Secreted protein

C_ch_105.390

cgd6_5490

0.98

NO

YES

YES

Conserved hypothetical protein with low sequence complexity regions

C_ch_1.56

cgd6_50

0.97

YES

NO

YES

Predicted secreted protein

C_ch_50.3279

cgd1_120

0.95

NO

YES

YES

Predicted secreted protein with a cysteine cluster at the C-terminus

C_ch_18.1418

cgd4_2900

0.93

NO

NO

NO

Polyketide synthase

C_ch_19.1673

cgd4_2510

0.92

NO

YES

NO

Predicted secreted protein

C_ch_19.1715

cgd3_2180

0.92

NO

NO

NO

Type I fatty acid synthase

C_ch_35.2958

cgd5_4610

0.89

YES

YES

YES

Conserved secreted protein

C_ch_23.2117

cgd4_1380

0.86

YES

NO

NO

ABC transporter with 2 AAA domains and 14 transmembrane regions

C_ch_50.3280

cgd1_130

0.82

YES

YES

YES

Predicted secreted protein with a cysteine cluster at the C-terminus

C_ch_17.1234

cgd7_3440

0.78

YES

YES

NO

Predicted secreted protein

C_ch_50.3278

cgd1_110

0.77

NO

YES

YES

Predicted secreted protein

C_ch_21.2011

cgd8_40

0.76

YES

YES

YES

Predicted secreted protein of Cryptosporidium-specific SKSR gene family

Subtotal

–

–

11/20 (55.0%)

9/20 (45.0%)

14/20 (70.0%)

–