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Table 2 Main categories modulated in response to trans-chalcone* exposure

From: Trans-chalcone activity against Trichophyton rubrum relies on an interplay between signaling pathways related to cell wall integrity and fatty acid metabolism

ID

Gene product name

Fold change

Condition

Transduction signaling

 TERG_01124

RAN-interacting protein

+ 5.37

MMK + TChal

 TERG_05617

Hypothetical protein

−5.29

MMK + TChal

 TERG_05744

GTP-binding protein

−6.87

MMK + TChal

 TERG_02263

Hypothetical protein

−5.29

MMK + TChal

 TERG_04042

Serine threonine protein kinase

−8.07

MMK + TChal

 TERG_00315

RAN protein kinase

−6.02

MMK + TChal

 TERG_00077

Eukaryotic peptide chain release Factor GTP-binding subunit

−6.72

MMK + TChal

 TERG_04867

SAM and pH domain-containing protein

−11.78

MMK + TChal

 TERG_07136

Farnesyltransferase beta subunit ram1

−9.29/−5.37

MMK + TChal/MMNG+TChal

 TERG_05617

Hypothetical protein

−12.39

MMNG+TChal

 TERG_00749

Guanine nucleotide exchange

−15.78

MMNG+TChal

 TERG_04523

CMGC CDKL CRK7 protein kinase

−5.02

MMNG+TChal

 TERG_01365

GTP-binding protein

−5.2

MMNG+TChal

 TERG_11963

DEAD/DEAH box RNA helicase

−7.48

MMNG+TChal

 TERG_01365

GTP-binding protein

−5.2

MMNG+TChal

 TERG_05987

GTP-binding protein

+ 8.17

MMNG+TChal

 TERG_01693

Acyl oxidase

−6.42

MMNG+TChal

 TERG_02422

RHO GTPase activator

+ 2.18

MME + TChal

 TERG_00689

AUR protein kinase

+ 3.34

MME + TChal

 TERG_07570

G-protein signaling

−2.35

MME + TChal

 TERG_04086

GTP-binding protein 1

−2.36

MME + TChal

 TERG_00548

Elongation factor 1 alpha

− 2.6

MME + TChal

 TERG_05987

GTP-binding protein

−3.32

MME + TChal

Fatty acid and lipid metabolism

 TERG_11538

3-oxoacyl-(acyl-carrier-protein) reductase

−7.45/−10.61

MMK + TChal/MMNG_TChal

 TERG_11813

FAD binding domain-containing protein

+ 5.95

MMK + TChal

 TERG_11814

FAD dependent protein

+ 10.63

MMK + TChal

 TERG_08235

Long-chain fatty alcohol oxidase

−5.52

MMNG+TChal

 TERG_04851

Acyl binding protein family

−2.30

MMNG+TChal

 TERG_02787

Fatty acid synthase S-acetyl transferase

−5.60

MMNG+TChal

 DW707302.1

Enoyl reductase

+ 4.09

MME + TChal

 TERG_07644

Ketoacyl reductase

+ 3.38

MME + TChal

TCA and glyoxylate cycle

 TERG_03483

Carnitine acetyltransferase

−5.48

MMK + TChal

 DW687355.1

Adenylsuccinate lyase

−15.01

MMK + TChal

 TERG_05484

Acyl dehydrogenase

+ 6.35

MMK + TChal

 TERG_01281

Malate glyoxomal

+ 5.11

MMNG+TChal

 TERG_01052

Succinyl ketoacyl transferase

+ 5.1

MMNG+TChal

 DW700277.1

Citrate synthase

−6.27

MMNG+TChal

 TERG_05484

Acyl dehydrogenase

+ 6.35

MMK + TChal

 TERG_04250

Carnitinyl- dehydratase

+ 2.13

MME + TChal

 TERG_01271

Isocitrate lyase

+ 2.04

MME + TChal

 TERG_01272

Methylcitrate mitochondrial

+ 2.49/+ 5.92

MME + TChal/MMNG+TChal

  1. *TChal: trans-chalcone added at 0.24 Όg/mL. +: induction; −: repression