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Table 4 Predicted upstream regulators of endometrial genes differentially expressed at week 9 (day 13 of the estrous cycle) in response to WK1_PC2

From: Concurrent and long-term associations between the endometrial microbiota and endometrial transcriptome in postpartum dairy cows

Upstream regulator Z-scorea P-value Differentially expressed genes (week 9)c
Bacterial products
 Mma_DMAGb 2.45 5.67E-08 CCL20, CXCL2, NFKBIZ, SDC4, SOD2, TNIP3
 Enterotoxin B 2.41 2.88E-08 CSF3, CTLA4, CXCL13, CXCL2, IL12B, IL17A
 Lipopolysaccharide 3.63 9.88E-10 CCL20, CHI3L1, CSF3, CXCL13, CXCL2, IFNW1, IL12B, IL17A, IL22, IL36A, LAMB1, LCN2, LYN, NFKBIZ, PC, PFKFB3, RAB20, SDC4, SOD2, TNIP3
 Peptidoglycan 2.39 2.65E-07 CCL20, CSF3, CXCL2, IL12B, IL17A, SOD2
Interleukins
 IL1 2.28 1.40E-06 CCL20, CHI3L1, CSF3, IL17A, IL22, LAMB1, SDC4, SOD2
 IL1A 2.56 6.29E-08 ALDH1A3, CCL20, CXCL2, IL12B, IL17A, LCN2, NFKBIZ, SOD2
 IL1B 3.39 1.30E-09 CCL20, CHI3L1, CSF3, CXCL13, CXCL2, GDF15, IL12B, IL17A, IL22, IL36A, LCN2, NFKBIZ, SDC4, SLC22A4, SOD2
 IL6 2.75 5.56E-05 CCL20, CLEC10A, CXCL13, CXCL2, IL12B, IL17A, IL22, LCN2, SOD2
 IL10RA −2.00 9.07E-04 CTLA4, IL12B, IL17A, IL18BP, LCN2
 IL17A 2.18 5.87E-08 CCL20, CSF3, CXCL13, CXCL2, IL17A, IL22, LCN2, NFKBIZ
Tumor necrosis factor 3.62 2.72E-12 AATK, ALDH1A3, CCL20, CHI3L1, CHI3L2, CSF3, CTLA4, CXCL13, CXCL2, GDF15, IL12B, IL17A, IL18BP, IL22, IL36A, ITGA10, LCN2, LYN, NFKBIZ, PC, SDC4, SLC22A4, SOD2
Toll-like receptors
 TLR3 2.91 8.70E-09 CCL20, CSF3, CXCL2, IFNW1, IL12B, IL36A, LCN2, NFKBIZ, PFKFB3
 TLR4 2.88 1.04E-09 CCL20, CSF3, CXCL2, DUOX2, IFNW1, IL12B, IL17A, IL18BP, LCN2, NFKBIZ, SOD2
 TLR5 2.18 2.81E-08 CCL20, CSF3, CXCL2, IL12B, IL17A
 TLR7 2.39 1.52E-06 CCL20, CXCL13, CXCL2, IFNW1, IL12B, SOD2
 TLR9 2.57 1.07E-06 CSF3, IFNW1, IL12B, IL36A, LCN2, NFKBIZ, PFKFB3
  1. apositive z-score = increased activation; negative z-score = decreased activation
  2. b5-O-mycolyl-beta-araf-(1 → 2)-5-O-mycolyl-alpha-araf-(1 → 1′)-glycerol
  3. cSee Additional file 1: Table S10 for gene description