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Table 2 Lists of the significantly enriched KEGG pathways associated with immune responses

From: Transcriptome analysis reveals differential immune related genes expression in bovine viral diarrhea virus-2 infected goat peripheral blood mononuclear cells (PBMCs)

Pathways ID DEGs No. p-value Up-regulated genes Down-regulated genes
Cytokine-cytokine receptor interaction ko04060 29 5.04E-06 CCL4,CCL3,CXCL10,IL17A,IL12B,IL19,IL10, XCL1,CCL5,CCL22,IL6,CCL20,GM-CSF,TNF, TNFRSF13C,TNFRSF8, TNFRSF9 TNFSF12,CSF1R,regakine-1,CCL2,TNFRSF21, CSF3R,CCL24,CCL17,CCL14,IL5RA,CCL25, PPBP
NOD-like receptor signaling pathway ko04621 11 1.01E-05 TNFAIP3,NFKBIA,IL6,TNF,CCL5 CARD9,MAPK11,NLRP1,CCL2,MAPK13,NOD1
TNF signaling pathway ko04668 15 5.59E-05 TNF,NFKBIA,CCL5,IL6,TNFAIP3,EDN1,PTGS2,CCL20,ICAM1,GM-CSF,CXCL10 MAPK11,CREB3L2,CCL2,MAPK13
Chemokine signaling pathway ko04062 19 0.000168 CCL3,CCL20,CXCL10,CCL4,CCL5,CCL22, XCL1,NFKBIA, GNG7 CCL17,CCL24,PAK1,CCL25,regakine-1,CCL2,CCL14,GNB4,GNG12,PPBP
Complement and coagulation cascades ko04610 11 0.000286 C3,SERPING1,CR2 C1QA, C1QB,C1QC, CFD, F13A1,C5AR1, CD55, LOC102185401
Toll-like receptor signaling pathway ko04620 13 0.000434 IL12B,CCL3,CXCL10,TNF,NFKBIA,CCL4, CCL5,IL6 CD14,MAPK11,CD86,regakine-1,MAPK13