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Table 8 Statistics for predicted variants in human membrane proteome

From: Benchmarking subcellular localization and variant tolerance predictors on membrane proteins

 

Total

Outer

Transmembrane

Inner

Number of proteins

5422

Number of predicted proteins

5070

Predicted proteins (%)

93.51

Number of amino acids

2,983,503

1,458,196

456,186

1,069,121

Number of predicted amino acids

2,850,519

1,367,843

434,745

1,047,931

Predicted amino acids (%)

95.54

93.80

95.30

98.02

Number of possible variants in all proteins/region

56,686,557

27,705,724

8,667,534

20,313,299

Number of possible variants in predicted proteins/region

54,159,861

25,989,017

8,260,155

19,910,689

Number of predicted variants

53,310,412

25,558,804

8,169,606

19,581,983

Predicted variants (% of possible)

98.43

98.34

98.90

98.35

Number of variants predicted as neutral

21,343,305

10,529,555

3,141,354

7,672,377

Neutral variants (%)

40.04

41.20

38.45

39.18

Average number of neutral variants per protein

4197.31

2070.71

617.77

1508.83

Median number of neutral variants per protein

2471

727

234

781

Number of variants predicted as pathogenic

9,760,571

4367,037

1,702,467

3,691,067

Pathogenic variants (%)

18.31

17.09

20.84

18.8

Average number of pathogenic variants per protein

1919.48

858.81

334.80

725.87

Median number of pathogenic variants per protein

173

19

2

20

Number of variants predicted as unknown

22,206,536

10,662,212

3,325,785

8,218,539

Unknown variants (%)

41.66

41.72

40.71

41.97

Average number of unknown variants per protein

4367.07

2096.80

654.04

1616.23

Median number of unknown variants per protein

3013

714

290

616

Ratio of pathogenic and neutral variants

0.46

0.41

0.54

0.48