Table 8 Statistics for predicted variants in human membrane proteome
From: Benchmarking subcellular localization and variant tolerance predictors on membrane proteins
| Â | Total | Outer | Transmembrane | Inner |
|---|---|---|---|---|
Number of proteins | 5422 | – | – | – |
Number of predicted proteins | 5070 | – | – | – |
Predicted proteins (%) | 93.51 | – | – | – |
Number of amino acids | 2,983,503 | 1,458,196 | 456,186 | 1,069,121 |
Number of predicted amino acids | 2,850,519 | 1,367,843 | 434,745 | 1,047,931 |
Predicted amino acids (%) | 95.54 | 93.80 | 95.30 | 98.02 |
Number of possible variants in all proteins/region | 56,686,557 | 27,705,724 | 8,667,534 | 20,313,299 |
Number of possible variants in predicted proteins/region | 54,159,861 | 25,989,017 | 8,260,155 | 19,910,689 |
Number of predicted variants | 53,310,412 | 25,558,804 | 8,169,606 | 19,581,983 |
Predicted variants (% of possible) | 98.43 | 98.34 | 98.90 | 98.35 |
Number of variants predicted as neutral | 21,343,305 | 10,529,555 | 3,141,354 | 7,672,377 |
Neutral variants (%) | 40.04 | 41.20 | 38.45 | 39.18 |
Average number of neutral variants per protein | 4197.31 | 2070.71 | 617.77 | 1508.83 |
Median number of neutral variants per protein | 2471 | 727 | 234 | 781 |
Number of variants predicted as pathogenic | 9,760,571 | 4367,037 | 1,702,467 | 3,691,067 |
Pathogenic variants (%) | 18.31 | 17.09 | 20.84 | 18.8 |
Average number of pathogenic variants per protein | 1919.48 | 858.81 | 334.80 | 725.87 |
Median number of pathogenic variants per protein | 173 | 19 | 2 | 20 |
Number of variants predicted as unknown | 22,206,536 | 10,662,212 | 3,325,785 | 8,218,539 |
Unknown variants (%) | 41.66 | 41.72 | 40.71 | 41.97 |
Average number of unknown variants per protein | 4367.07 | 2096.80 | 654.04 | 1616.23 |
Median number of unknown variants per protein | 3013 | 714 | 290 | 616 |
Ratio of pathogenic and neutral variants | 0.46 | 0.41 | 0.54 | 0.48 |