Skip to main content

Table 8 Statistics for predicted variants in human membrane proteome

From: Benchmarking subcellular localization and variant tolerance predictors on membrane proteins

  Total Outer Transmembrane Inner
Number of proteins 5422
Number of predicted proteins 5070
Predicted proteins (%) 93.51
Number of amino acids 2,983,503 1,458,196 456,186 1,069,121
Number of predicted amino acids 2,850,519 1,367,843 434,745 1,047,931
Predicted amino acids (%) 95.54 93.80 95.30 98.02
Number of possible variants in all proteins/region 56,686,557 27,705,724 8,667,534 20,313,299
Number of possible variants in predicted proteins/region 54,159,861 25,989,017 8,260,155 19,910,689
Number of predicted variants 53,310,412 25,558,804 8,169,606 19,581,983
Predicted variants (% of possible) 98.43 98.34 98.90 98.35
Number of variants predicted as neutral 21,343,305 10,529,555 3,141,354 7,672,377
Neutral variants (%) 40.04 41.20 38.45 39.18
Average number of neutral variants per protein 4197.31 2070.71 617.77 1508.83
Median number of neutral variants per protein 2471 727 234 781
Number of variants predicted as pathogenic 9,760,571 4367,037 1,702,467 3,691,067
Pathogenic variants (%) 18.31 17.09 20.84 18.8
Average number of pathogenic variants per protein 1919.48 858.81 334.80 725.87
Median number of pathogenic variants per protein 173 19 2 20
Number of variants predicted as unknown 22,206,536 10,662,212 3,325,785 8,218,539
Unknown variants (%) 41.66 41.72 40.71 41.97
Average number of unknown variants per protein 4367.07 2096.80 654.04 1616.23
Median number of unknown variants per protein 3013 714 290 616
Ratio of pathogenic and neutral variants 0.46 0.41 0.54 0.48