Skip to main content

Table 4 Slope of the regression lines of the normalized SBS frequency as a function of the vIP of the corresponding wild-type nucleotide motifs in the different gene regions

From: Relation between DNA ionization potentials, single base substitutions and pathogenic variants

X Doublets XN Triplets NXN Quadruplets NXNN Quintuplets NNXNN Sextuplets NNXNNN
Missense mutations in exons
All -0.6 -1.1 -1.1 -1.3 -1.5
Synonymous mutations in exons
All -1.4 -1.8 -2.1 -2.4 -2.6
Mutations in introns
All -1.8 -3.7 -3.7 -4.4 -5.3
Mutations in UTRs
All -0.9 -1.4 -1.4 -1.5 -1.7
  1. X indicates the position of the mutated nucleobase and N any base