Table 2 Top 35 ab initio predicted extracellular secreted proteins which received a meaningful functional annotation. Mode = Secretory mode: C = Classical secretory pathway (Predicted by SignalP5.0); NC = Non-classical secretory pathway (Predicted by SecretomeP2.0). FC = Log₂ fold change of gene expression

2358

NC

Deleted in malignant brain tumors 1 protein

1 Spermadhesin, CUB domain,2 SRCR-like

7203

NC

Coagulation factor XI

1 Trypsin-like serine proteases

5888

C

Chymotrypsinogen B

1 Trypsin-like serine proteases

5529

C

Collagen triple helix repeat-containing protein 1

–

25995

C

Heme-binding protein 2

1 Probable bacterial effector-binding domain

24564

C

Short-chain collagen C4 (Fragment)

–

11959

C

Matrix metalloproteinase-24

1 PGBD-like

23885

NC

Nematocyte expressed protein 6

1 Metalloproteases (“zincins”), catalytic domain

28234

C

Blastula protease 10

1 Metalloproteases (“zincins”), catalytic domain

26183

C

Dorsal-ventral patterning tolloid-like protein 1

2 Spermadhesin, CUB domain

8891

C

EGF-like repeat and discoidin I-like domain-containing protein 3

5 Galactose-binding domain-like

7095

NC

Deleted in malignant brain tumors 1 protein

–

4050

C

Cubilin

2 Concanavalin A-like lectins/glucanases,4 Spermadhesin, CUB domain

17639

C

Semaphorin-5B

3 CalX-like,6 TSP-1 type 1 repeat

14619

NC

Golgi-associated plant pathogenesis-related protein 1

1 PR-1-like

27786

C

Agrin

10 Kazal-type serine protease inhibitors

1814

C

Nephronectin

2 Growth factor receptor domain

3178

C

Toxin AvTX-60A

–

18607

C

Golgi-associated plant pathogenesis-related protein 1

1 PR-1-like

19786

C

Inactive pancreatic lipase-related protein 1

1 alpha/beta-Hydrolases,1 Lipase/lipooxygenase domain (PLAT/LH2 domain)

17513

NC

Neuronal pentraxin-2

1 Concanavalin A-like lectins/glucanases,1 Integrin alpha N-terminal domain

894

C

Protransforming growth factor alpha

1 EGF/Laminin

4815

NC

Hemicentin-1

4 TSP-1 type 1 repeat

28816

C

Blastula protease 10

1 Concanavalin A-like lectins/glucanases,1 Metalloproteases (“zincins”), catalytic domain,1 TSP-1 type 1 repeat

6291

NC

Golgi-associated plant pathogenesis-related protein 1

1 PR-1-like

14545

NC

Venom prothrombin activator oscutarin-C non-catalytic subunit

1 Family A G protein-coupled receptor-like,1 Galactose-binding domain-like

17088

C

Short-chain collagen C4 (Fragment)

–

7224

NC

Plasma kallikrein

1 Trypsin-like serine proteases

6481

C

Three prime repair exonuclease 2

1 Ribonuclease H-like

13236

C

Collagen triple helix repeat-containing protein 1

–

10560

C

Chondroitin proteoglycan 2

11 Invertebrate chitin-binding proteins

16517

C

Disintegrin and metalloproteinase domain-containing protein 10

–

20335

C

Collagen alpha-1(XXVII) chain

–

25531

NC

Fibronectin

1 Kringle-like

19685

C

Expansin-YoaJ

1 Barwin-like endoglucanases,1 Invertebrate chitin-binding proteins,1 PHL pollen allergen