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Table 2 Top 35 ab initio predicted extracellular secreted proteins which received a meaningful functional annotation. Mode = Secretory mode: C = Classical secretory pathway (Predicted by SignalP5.0); NC = Non-classical secretory pathway (Predicted by SecretomeP2.0). FC = Log2 fold change of gene expression

From: Transcriptional characterisation of the Exaiptasia pallida pedal disc

Aipgene Mode Annotation FC Protein superfamily domain (s)
2358 NC Deleted in malignant brain tumors 1 protein 6.47 1 Spermadhesin, CUB domain,2 SRCR-like
7203 NC Coagulation factor XI 4.67 1 Trypsin-like serine proteases
5888 C Chymotrypsinogen B 4.59 1 Trypsin-like serine proteases
5529 C Collagen triple helix repeat-containing protein 1 4.20
25995 C Heme-binding protein 2 3.82 1 Probable bacterial effector-binding domain
24564 C Short-chain collagen C4 (Fragment) 3.68
11959 C Matrix metalloproteinase-24 3.51 1 PGBD-like
23885 NC Nematocyte expressed protein 6 3.36 1 Metalloproteases (“zincins”), catalytic domain
28234 C Blastula protease 10 3.35 1 Metalloproteases (“zincins”), catalytic domain
26183 C Dorsal-ventral patterning tolloid-like protein 1 3.26 2 Spermadhesin, CUB domain
8891 C EGF-like repeat and discoidin I-like domain-containing protein 3 3.14 5 Galactose-binding domain-like
7095 NC Deleted in malignant brain tumors 1 protein 3.04
4050 C Cubilin 2.75 2 Concanavalin A-like lectins/glucanases,4 Spermadhesin, CUB domain
17639 C Semaphorin-5B 2.68 3 CalX-like,6 TSP-1 type 1 repeat
14619 NC Golgi-associated plant pathogenesis-related protein 1 2.53 1 PR-1-like
27786 C Agrin 2.50 10 Kazal-type serine protease inhibitors
1814 C Nephronectin 2.47 2 Growth factor receptor domain
3178 C Toxin AvTX-60A 2.45
18607 C Golgi-associated plant pathogenesis-related protein 1 2.44 1 PR-1-like
19786 C Inactive pancreatic lipase-related protein 1 2.37 1 alpha/beta-Hydrolases,1 Lipase/lipooxygenase domain (PLAT/LH2 domain)
17513 NC Neuronal pentraxin-2 2.34 1 Concanavalin A-like lectins/glucanases,1 Integrin alpha N-terminal domain
894 C Protransforming growth factor alpha 2.33 1 EGF/Laminin
4815 NC Hemicentin-1 2.33 4 TSP-1 type 1 repeat
28816 C Blastula protease 10 2.31 1 Concanavalin A-like lectins/glucanases,1 Metalloproteases (“zincins”), catalytic domain,1 TSP-1 type 1 repeat
6291 NC Golgi-associated plant pathogenesis-related protein 1 2.29 1 PR-1-like
14545 NC Venom prothrombin activator oscutarin-C non-catalytic subunit 2.25 1 Family A G protein-coupled receptor-like,1 Galactose-binding domain-like
17088 C Short-chain collagen C4 (Fragment) 2.24
7224 NC Plasma kallikrein 2.23 1 Trypsin-like serine proteases
6481 C Three prime repair exonuclease 2 2.23 1 Ribonuclease H-like
13236 C Collagen triple helix repeat-containing protein 1 2.22
10560 C Chondroitin proteoglycan 2 2.17 11 Invertebrate chitin-binding proteins
16517 C Disintegrin and metalloproteinase domain-containing protein 10 2.13
20335 C Collagen alpha-1(XXVII) chain 2.13
25531 NC Fibronectin 2.13 1 Kringle-like
19685 C Expansin-YoaJ 2.12 1 Barwin-like endoglucanases,1 Invertebrate chitin-binding proteins,1 PHL pollen allergen