Skip to main content

Advertisement

Table 3 Estimated group effect on a gene by lncDIFF on simulated low-abundance expression. Low-abundance expressions were sampled from three statistical distributions and two scenarios of parameters (defined by β ’s and CV). 1000 replicates were generated resulting in 1000 estimates per scenario

From: lncDIFF: a novel quasi-likelihood method for differential expression analysis of non-coding RNA

Sampling Distribution Groups Baseline Group A Contrast B vs A Contrast C vs A Baseline Group A Contrast B vs A Contrast C vs A
True Parameter βi1 = 2 (CV = 1.75) βi2 = 3 (CV = 1.45) βi2 = 8 (CV = 1.26) βi1 = 2 (CV = 1) βi2 = 3 (CV = 0.7) βi2 = 8 (CV = 0.6)
Exponential (CV = 1) Mean 1.98 3.03 7.91 1.98 3.03 7.91
Median 1.97 3.02 7.85 1.97 3.02 7.85
Negative Binomial Mean 1.99 3.00 8.03 2.00 3.01 8.06
Median 1.98 2.96 7.97 2.00 3.01 8.02
Log Normal Mean 1.99 2.99 7.98 1.99 3.00 8.02
Median 1.95 2.92 7.82 1.97 2.95 7.95