Fig. 1

NUCLIZE: defining histone modification at single-nucleosome resolution. (a) Schematic view of the NUCLIZE approach for re-annotating histone modification data at single-nucleosome resolution. (b) The NUCLIZE Workflow. (c) Examples of single and multivalent histone modification signals at each nucleosome position near the TSS of a highly expressed gene, ASGR2, in HepG2 cells. Each color represents one single or multivalent histone modification mark in each nucleosome from combined analysis of all five histone marks