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Table 4 Ingenuity Pathway Analysis canonical pathways associated with heifer conception rate (B-H P < 0.01)

From: Validation of 46 loci associated with female fertility traits in cattle

Canonical Pathwaysa

B-H P-valueb

Positional Candidates Genes

cAMP-Mediated Signaling

0.0041

ADCY5, AKAP9, CAMK2D, CHRM3, CNGA3, ENPP6, GRM8, PDE11A, PDE4D, PDE5A, RGS10, RGS7

G-Protein Coupled Receptor Signaling

0.0041

ADCY5, CAMK2D, CHRM3, ENPP6, GNAQ, GRM8, IKBKE, PDE11A, PDE4D, PDE5A, PIK3CB, PIK3R1, RGS10, RGS7

  1. a Canonical pathways identified in the Ingenuity Pathway Analysis with positional candidate genes associated with heifer conception rate at first service and/or the number of times bred to become pregnant
  2. b Benjamini-Hochberg multiple testing correction significance value for the Ingenuity Pathway Analysis
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BMC Genomics

ISSN: 1471-2164

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