Promoter conservation in HDACs points to functional implications

BMC Genomics

Table 1 Genomic location, amino acid length of the main isoform, number of biochemically characterized active sites, and cellular localization of human histone deacetylases

		Chm	Protein length of main isoform (aa)	Number of active sites	Present in nucleus	Present in cytoplasm
Class I	HDAC1	1p34.1	482	1	P	N (If present, results in axonal damage [2])
	HDAC2	6q21	488	1	P	N
	HDAC3	5q31.2	428	1	P	P
	HDAC8	Xq13	377	1	P	P [3]
Class IIA	HDAC4	2q37.2	1084	1	P	P
	HDAC5	17q21	1122	1	P	P
	HDAC7	12q13.1	952	1	P	P
	HDAC9	7p21.1	1011	1	P	P
Class IIB	HDAC6	Xp11.23	1215	2	P	P
Class IIB	HDAC10	22q13.31	669	1	P	P
Class IV	HDAC11	3p25.1	347	1	P	P

Data from the NCBI Gene database, and localization data from [1], except where shown. P present, N Not present

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