Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis

BMC Genomics

Table 1 The expression of 20 novel candidate transcription factors in cerebellar development (bolded genes are those examined with qRT-PCR and in utero knock-down). Five genes well known in cerebellar development with their expression levels for comparison are shown at the bottom of the table, in italics

Refseq	Gene symbol	Mean	Max	KO phenotype	Eur-express	Allen Brain
NM_010496	Id2	341	529	postnatal lethality		Y
NM_057172	Fubp1	252	469	NO KO
NM_011865	Pcbp1	212	365	NO KO		Y
NM_016889	Insm1	74	183	perinatal and neonatal lethality	Y
NM_001160410	Scrt2	80	180	NO KO	Y
NM_001008542	Mxi1	90	168	progressive hyperplasia in the spleen and prostate		Y
NM_009716	Atf4	117	167	postnatal lethality		Y
NM_130893	Scrt1	76	161	NO KO
NM_001103165	Pcbp2	90	147	NO KO
NM_001024918	Rfx4	52	138	missing dorsal-mid line structure of the cortex, neonatal lethality		Y
NM_009628	Adnp	100	132	embryonic death between E8.5 and E9
NM_010772	Maz	101	128	NO KO		Y
NM_011265	Rfx3	77	127	embryonic and perinatal lethality,		Y
NM_181322	Ctcf	86	120	die prior to E9.5
NM_013780	Npas3	56	114	exhibit abnormal behavior and nervous system morphology	Y
NM_001085492	Rere	65	88	embryonic lethality with abnormalities in neural tube development
NM_011732	Ybx1	60	86	embryonic and perinatal lethality
NM_001093776	Myt1l	49	85	NO KO		Y
NM_023739	Nfx1	74	84	NO KO
NM_015753	Zeb2	41	83	embryonic death between embryonic days 9.5 and 10.5		Y
Expression of genes known to cerebellar development
NM_010894	Neurod1	299	1035
NM_009573	Zic1	216	408
NM_001244200	Pax6	58	107
NM_001289916	Rora	35	59
NM_007500	Atoh1	28	58

ISSN: 1471-2164