Table 2 QTLs identified in R/qtl analyses
From: Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci
Cross (#HD / #Unaffected) | Chr position (@ peak SNP) | LOD Score | % Variance Explained | Level of Significancea | Haplotype-defined interval Chr: Mb range (size of interval) |
|---|---|---|---|---|---|
D2.HD-N2 (19 / 6) | 5:147147276 | 3.32 | 43.2 | suggestive | 5:143159090–151734385 (8.58 Mb) |
D2.HD-F2 (16 / 16) | – | – | – | – | 5:144329217–147894899 (3.57 Mb) |
SJ.HD-N2 (16 / 17) | 5:148558183 | 4.88 | 47.4 | highly significant (Emhd1) | 5:129525220–151734385 (22.21 Mb) |
SJ.HD-F2 (22 / 22) | – | – | – | – | 5:145128608–147778059 (2.65 Mb) |
17:21456192 | 7.51 | 52.9 | highly significant (Emhd2) | 17:15358323–23816187 (8.46 Mb) | |
17:35308100 | 6.89 | 49.6 | highly significant (Emhd3) | 17:31471362–46058209 (14.59 Mb) | |
SJ.HD-N2 + F2 (38 / 39) | 1:176044015 | 4.12 | 21.3 | significant | 1:172969406–194625219 (23.59 Mb) |
5:146601763 | 5.79 | 28.6 | highly significant (Emhd1) | 5:143159090–151734385 (8.58 Mb) | |
17:17933928 | 6.53 | 35.1 | highly significant (Emhd2) | same as F2 | |
17:35308100 | 7.43 | highly significant (Emhd3) | same as F2 |