Signatures of selection for resistance to Haemonchus contortus in sheep and goats

Estrada-Reyes, Zaira M.; Tsukahara, Yoko; Amadeu, Rodrigo R.; Goetsch, Arthur L.; Gipson, Terry A.; Sahlu, Tilahun; Puchala, Richard; Wang, Zaisen; Hart, Steve P.; Mateescu, Raluca G.

doi:10.1186/s12864-019-6150-y

BMC Genomics

Table 1 Signatures of selection identified between resistant (Katahdin or St. Croix) and susceptible (Dorper) sheep breeds. Breeds compared (comparison), gene name, gene region, SNP name (chromosome and position), SNP, mutation type (synonymous or missense), and Fst value for the SNPs under selection

From: Signatures of selection for resistance to Haemonchus contortus in sheep and goats

Comparison	Gene	Region	SNP name	SNP	MAF	Mutation	Fst (Bayesian)	Fst (Frequentist)	alpha
Katahdin and St. Croix vs Dorper (Resistant and Resistant vs Susceptible)	CSF3	5’UTR	OAR11:39857496	G/A	Dorper: 0.20, Katahdin: 0.19, Spanish: 0.35		0.31	0.35	1
	NOS2	Exon 7	OAR11:18963484	A/G	Dorper: 0.21, Katahdin: 0.19, Spanish: 0.23	Synonymous (Ile → Ile)	0.36	0.35	0.67
	NOS2	Exon 16	OAR11:18963494	T/C	Dorper: 0.20, Katahdin: 0.19, Spanish: 0.25	Synonymous (Leu → Leu)	0.33	0.35	0.55
	TGFB2	3’UTR	OAR12:19965761	A/C	Dorper: 0.20, Katahdin: 0.12, Spanish: 0.16		0.26	0.57	0.52
	IL2RA	Intron 5	OAR13:10442920	C/A	Dorper: 0.55, Katahdin: 0, Spanish: 0		0.24	0.21	0.6
	IL2RA	Intron 5	OAR13:10442953	A/G	Dorper: 0.43, Katahdin: 0, Spanish: 0		0.23	0.21	0.55
Katahdin vs Dorper (Resistant vs Susceptible)	SOCS2	Exon 2	OAR3:129558034	C/T	Dorper: 0.20, Katahdin: 0.19	Synonymous (Ile → Ile)	0.25	0.6	0.53
	SOCS2	3′ UTR	OAR3:129558430	G/A	Dorper: 0.20, Katahdin: 0.19		0.21	0.56	0.39
	NOS2	Exon 7	OAR11:18963484	A/G	Dorper: 0.21, Katahdin: 0.19	Synonymous (Ile → Ile)	0.36	0.59	1
	NOS2	Exon 16	OAR11:18963494	T/C	Dorper: 0.20, Katahdin: 0.19	Synonymous (Leu → Leu)	0.33	0.56	0.97
	TGFB2	3’UTR	OAR12:19965761	A/C	Dorper: 0.20, Katahdin: 0.12		0.26	0.57	0.6
	TGFB2	3’UTR	OAR12:19965865	A/C	Dorper: 0.05, Katahdin: 0.29		0.25	0.51	0.5
	IL2RA	Intron 5	OAR13:10442920	C/A	Dorper: 0.55, Katahdin: 0		0.24	0.21	0.42
	IL2RA	Intron 5	OAR13:10442953	A/G	Dorper: 0.43, Katahdin: 0		0.23	0.22	0.39
St. Croix vs Dorper (Resistant vs Susceptible)	C3AR1	3’UTR	OAR3:206099209	T/A	Dorper: 0, Spanish: 0.42		0.21	0.35	0.52
	CSF3	5’UTR	OAR11:39857496	G/A	Dorper: 0.20, Spanish: 0.35		0.34	0.48	1
	STAT5B	Intron 16	OAR11:41755713	G/A	Dorper: 0.20, Spanish: 0.48		0.28	0.36	0.76
	TGFB2	3’UTR	OAR12:19965761	A/C	Dorper: 0.20, Spanish: 0.16		0.23	0.55	0.49
	IL2RA	Intron 5	OAR13:10442920	C/A	Dorper: 0.55, Spanish: 0		0.21	0.21	0.4

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ISSN: 1471-2164

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